Literature DB >> 4338462

1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats.

M F Holick, M Garabedian, H F DeLuca.   

Abstract

Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D(3) responsible for bone calcium mobilization.

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Year:  1972        PMID： 4338462     DOI： 10.1126/science.176.4039.1146

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  32 in total

1.  The biological activity of synthetic 25,26-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol in vitamin D-deficient rats.

Authors:  L Miravet; J Redel; M Carre; M L Queillé; P Bordier
Journal:  Calcif Tissue Res       Date:  1976-12-02

Review 2.  The biology and pathology of vitamin D control in bone.

Authors:  Taison D Bell; Marie B Demay; Sherri-Ann M Burnett-Bowie
Journal:  J Cell Biochem       Date:  2010-09-01       Impact factor: 4.429

3.  The effects of 1,25-dihydroxycholecalciferol on embryonic bone in vitro: a biochemical and histological study.

Authors:  M P Herrmann-Erlee; P J Gaillard
Journal:  Calcif Tissue Res       Date:  1978-05-26

Review 4.  The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF).

Authors:  Luisella Cianferotti; Claudio Cricelli; John A Kanis; Ranuccio Nuti; Jean-Y Reginster; Johann D Ringe; Rene Rizzoli; Maria Luisa Brandi
Journal:  Endocrine       Date:  2015-05-01       Impact factor: 3.633

5.  Rickets.

Authors: 
Journal:  West J Med       Date:  1976-09

6.  Parathyroidectomy reduces 25-hydroxyvitamin D3-1 alpha-hydroxylase activity in the hypocalcemic vitamin D-deficient chick.

Authors:  B E Booth; H C Tsai; R C Morris
Journal:  J Clin Invest       Date:  1977-12       Impact factor: 14.808

7.  [Immunoreactive parathyroid hormone, 25-hydroxycalciferol and bone histology in renal osteodystrophy (author's transl)].

Authors:  G Offermann; K Schaefer; A Schulz; G Delling
Journal:  Klin Wochenschr       Date:  1976-07-01

Review 8.  History of the discovery of vitamin D and its active metabolites.

Authors:  Hector F Deluca
Journal:  Bonekey Rep       Date:  2014-01-08

9.  Metabolism of 1,25-dihydroxycholecalciferol in the rat.

Authors:  C A Frolik; H F DeLuca
Journal:  J Clin Invest       Date:  1972-11       Impact factor: 14.808

10.  Rapid enhancement of chick intestinal DNA-dependent RNA polymerase II activity by 1 alpha, 25-dihydroxyvitamin D3, in vivo.

Authors:  J E Zerwekh; M R Haussler; T J Lindell
Journal:  Proc Natl Acad Sci U S A       Date:  1974-06       Impact factor: 11.205
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