Literature DB >> 4338196

Reversion of murine sarcoma virus transformed mouse cells: variants without a rescuable sarcoma virus.

P J Fischinger, S Nomura, P T Peebles, D K Haapala, R H Bassin.   

Abstract

Murine sarcoma virus transformed mouse 3T3 cells, which are negative for murine leukemia virus and which yield sarcoma virus after superinfection with murine leukenmia virus, spotaneously give rise to flat variants front which murine sarcoma virus can no longer be rescued. The revertants support leukemia viruis growth and show an enhanced sensitivity to murine sarcoma superinfection and, like normal cells, do not release RNA-dependent DNA polymerase activity. Because revertants could be obtained with high frequency from progeny of single transformed cells, each cell that containts the sarconma virus genome seems to have the capacity to suppress or eliminate an RNA tumor virus native to its species of origin.

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Year:  1972        PMID： 4338196     DOI： 10.1126/science.176.4038.1033

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

1.  Comparative study of different isolates of murine sarcoma virus.

Authors:  D J Donoghue; P A Sharp; R A Weinberg
Journal:  J Virol       Date:  1979-12       Impact factor: 5.103

2.  Quantitation and localization of Rous sarcoma virus-specific RNA in transformed and revertant field vole cells.

Authors:  R A Krzyzek; A F Lau; P K Vogt; A J Faras
Journal:  J Virol       Date:  1978-02       Impact factor: 5.103

3.  Glucocorticoids induce focus formation and increase sarcoma viral expression in a mink cell line that contains a murine sarcoma viral genome.

Authors:  D R Lowy; E M Scolnick
Journal:  J Virol       Date:  1978-01       Impact factor: 5.103

4.  Chemical determination of the m1 Moloney sarcoma virus pP60gag gene order: evidence for unique peptides in the carboxy terminus of the polyprotein.

Authors:  M K Oskarsson; J H Elder; J W Gautsch; R A Lerner; G F Vande Woude
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

5.  Temperature-dependent expression of transformation by cold-sensitive mutant of murine sarcoma virus.

Authors:  K Somers; S Kit
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

6.  Selection of revertants of Kirsten sarcoma virus transformed nonproducer BALB-3T3 cells.

Authors:  B Ozanne; A Vogel
Journal:  J Virol       Date:  1974-08       Impact factor: 5.103

Review 7.  The molecular programme of tumour reversion: the steps beyond malignant transformation.

Authors:  Adam Telerman; Robert Amson
Journal:  Nat Rev Cancer       Date:  2009-01-30       Impact factor: 60.716

8.  Expression of the major internal viral polypeptide in cells transformed by wild-type and temperature-sensitive murine sarcoma virus.

Authors:  G Spira; G R Dreesman; M Benyesh-Melnick; S Kit; K D Somers
Journal:  J Virol       Date:  1974-11       Impact factor: 5.103

9.  Cloning of integrated Moloney sarcoma proviral DNA sequences in bacteriophage lambda.

Authors:  G F Vande Woude; M Oskarsson; L W Enquist; S Nomura; M Sullivan; P J Fischinger
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

10.  Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes.

Authors:  M Noda; Z Selinger; E M Scolnick; R H Bassin
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205
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