Literature DB >> 4338096

Iodine-125-labeled antibody to viral antigens: binding to the surface of virus-infected cells.

K Hayashi, J Rosenthal, A L Notkins.   

Abstract

The specific binding of iodine-125-labeled antibody to viral antigens can be used to detect newly synthesized viral antigens and determine the time of appearance of these antigens on the surface of infected cells. Incubation of infected cells with unlabeled antibody to viral antigens specifically blocks the attachment of labeled antibody, and by this inhibition technique the titer of unlabeled antibody to viral antigens can be calculated. The attachment of the labeled antibody to virus-infected cells offers an objective and sensitive method of detecting viral antigens and measuring antibody to virus.

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Year:  1972        PMID： 4338096     DOI： 10.1126/science.176.4034.516

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

1.  Polyoma virus strain with enhanced synthesis of capsid protein.

Authors:  T G Tachovsky; J D Hare
Journal:  J Virol       Date:  1975-07       Impact factor: 5.103

2.  The immune response to infection with vaccinia virus in mice. I. Infection and the production of antibody neutralizing cell-associated and cell-free virus.

Authors:  L M Hutt
Journal:  J Hyg (Lond)       Date:  1975-06

3.  Comparison of direct and indirect solid-phase microradioimmunoassays for the detection of viral antigens and antiviral antibody.

Authors:  J D Rosenthal; K Hayashi; A L Notkins
Journal:  Appl Microbiol       Date:  1973-04

4.  Solid-phase radioimmunoassay as a method for evaluating antigenic differences in type A influenza viruses.

Authors:  J H Schieble; D Cottam
Journal:  Infect Immun       Date:  1977-01       Impact factor: 3.441

5.  Solid phase radioimmunoassay for typing herpes simplex viral antibodies in human sera.

Authors:  B Forghani; N J Schmidt; E H Lennette
Journal:  J Clin Microbiol       Date:  1975-11       Impact factor: 5.948

6.  Expression of vaccinia virion surface tubule protein as a virus specific cell surface antigen.

Authors:  T O Harry
Journal:  Arch Virol       Date:  1978       Impact factor: 2.574

7.  Rubella virus and rheumatoid arthritis.

Authors:  H Hart; B P Marmion
Journal:  Ann Rheum Dis       Date:  1977-02       Impact factor: 19.103

8.  Immunoprecipitation of herpes simplex virus type 1 antigens with different antisera and human cerebrospinal fluids.

Authors:  G Pauli; H Ludwig
Journal:  Arch Virol       Date:  1977       Impact factor: 2.574

9.  Solid phase radioimmunoassay for identification of Herpesvirus hominis types 1 and 2 from clinical materials.

Authors:  B Forghani; N J Schmidt; E H Lennette
Journal:  Appl Microbiol       Date:  1974-10

10.  Prevention of cell-to-cell spread of herpes simplex virus by leukocytes.

Authors:  D L Lodmell; A Niwa; K Hayashi; A L Notkins
Journal:  J Exp Med       Date:  1973-03-01       Impact factor: 14.307
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