Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma.

Literature DB >> 4335063

Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma.

Abstract

A procedure is described permitting the detection of viral-specific RNA in a mouse mammary tumor. The method involves molecular hybridization with radioactively labeled DNA complementary to the RNA of the mouse mammary-tumor virus. RNA homologous to that of the mammary agent has been found in both the nuclear and polyribosomal fractions of tumor cells. The results imply that the oncogenic information is serving as messenger RNA that directs the synthesis of proteins required for virus production, and perhaps for the maintenance of the neoplastic state. The technology developed is immediately applicable to tumors of human origin.

Entities: Disease Species

Mesh：

Substances：

Year: 1972 PMID： 4335063 PMCID： PMC426501 DOI： 10.1073/pnas.69.3.535

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

9 in total

1. Sequence complementarity of T2-DNA and T2-specific RNA.

Authors: B D HALL; S SPIEGELMAN
Journal: Proc Natl Acad Sci U S A Date: 1961-02-15 Impact factor: 11.205

2. RNA-dependent DNA polymerase activity in virus-like particles isolated from human milk.

Authors: J Schlom; S Spiegelman; D Moore
Journal: Nature Date: 1971-05-14 Impact factor: 49.962

3. SV40-specific RNA in the nucleus and polyribosomes of transformed cells.

Authors: U Lindberg; J E Darnell
Journal: Proc Natl Acad Sci U S A Date: 1970-04 Impact factor: 11.205

4. Characterization of the products of DNA-directed DNA polymerases in oncogenic RNA viruses.

Authors: S Spiegelman; A Burny; M R Das; J Keydar; J Schlom; M Travnicek; K Watson
Journal: Nature Date: 1970-08-08 Impact factor: 49.962

5. Search for a human breast cancer virus.

Authors: D H Moore; J Charney; B Kramarsky; E Y Lasfargues; N H Sarkar; M J Brennan; J H Burrows; S M Sirsat; J C Paymaster; A B Vaidya
Journal: Nature Date: 1971-02-26 Impact factor: 49.962

6. Mechanism of viral carcinogenesis by deoxyribonucleic acid mammalian viruses. IV. Related virus-specific ribonucleic acids in tumor cells induced by "highly" oncogenic adenovirus types 12, 18, and 31.

Authors: K Fujinaga; M Green
Journal: J Virol Date: 1967-06 Impact factor: 5.103

7. [Acute poisoning in a central hospital. 381 consecutive cases from a 4-year period].

Authors: J Dinesen; N Haagensen
Journal: Ugeskr Laeger Date: 1968-05-02

8. Virus specific RNA in cells transformed by RNA tumour viruses.

Authors: M Green; H Rokutanda; M Rokutanda
Journal: Nat New Biol Date: 1971-04-21

9. RNA metabolism in the HeLa cell nucleus.

Authors: S Penman
Journal: J Mol Biol Date: 1966-05 Impact factor: 5.469

9 in total

16 in total

10. Virus-specific messenger RNA on free and membrane-bound polyribosomes from cells infected with Rauscher leukemia virus.

Authors: A L Gielkens; M H Salden; H Bloemendal
Journal: Proc Natl Acad Sci U S A Date: 1974-04 Impact factor: 11.205

Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma.

1. Sequence complementarity of T2-DNA and T2-specific RNA.

2. RNA-dependent DNA polymerase activity in virus-like particles isolated from human milk.

3. SV40-specific RNA in the nucleus and polyribosomes of transformed cells.

4. Characterization of the products of DNA-directed DNA polymerases in oncogenic RNA viruses.

5. Search for a human breast cancer virus.

6. Mechanism of viral carcinogenesis by deoxyribonucleic acid mammalian viruses. IV. Related virus-specific ribonucleic acids in tumor cells induced by "highly" oncogenic adenovirus types 12, 18, and 31.

7. [Acute poisoning in a central hospital. 381 consecutive cases from a 4-year period].

8. Virus specific RNA in cells transformed by RNA tumour viruses.

9. RNA metabolism in the HeLa cell nucleus.

1. Size of murine RNA tumor virus-specific nuclear RNA molecules.

2. Nucleic acid hybridization with RNA immobilized on filter paper.

3. Detection of RNA-instructed DNA polymerase and high molecular weight RNA in malignant tissue.

4. Integration of measles virus nucleic acid into the cell genome.

5. Isolation of a leukovirus from a continuous human cell line.

6. Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro.

7. Incorporation of viral genome in DNA of chronically infected cells.

8. RNA related to that of a murine leukemia virus in Burkitt's tumors and nasopharyngeal carcinomas.

9. Viral-related RNA in Hodgkins' disease and other human lymphomas.

10. Virus-specific messenger RNA on free and membrane-bound polyribosomes from cells infected with Rauscher leukemia virus.