Literature DB >> 4332823

Modulation of adenylate cyclase activity in liver and fat cell membranes by insulin.

G Illiano, P Cuatrecasas.   

Abstract

Insulin depresses both the activity of adenylate cyclase stimulated by glucagon, epinephrine, and sodium fluoride in liver cell membranes and the activity of adenylate cyclase stimulated by epinephrine and adrenocorticotropin in particulate preparations from homogenates of isolated fat cells. Significant inhibition is detected with very low concentrations (10(-11) molar) of insulin but not with unphysiologically high (10(-9)molar) concentrations of the hormone. These direct effects of insulin on an enzymatic system in broken-cell -preparations suggest a fundamental role of adenylate cyclase activity and of cyclic adenosine monophosphate in the mechanism of action of insulin.

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Year:  1972        PMID： 4332823     DOI： 10.1126/science.175.4024.906

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  Cellular levels of feedback regulator of adenylate cyclase and the effect of epinephrine and insulin.

Authors:  R j Ho; T R Russell; T Asakawa; E W Sutherland
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

2.  The properties and extracellular location of 5'-nucleotidase of the rat fat-cell plasma membrane.

Authors:  A C Newby; J P Luzio; C N Hales
Journal:  Biochem J       Date:  1975-03       Impact factor: 3.857

Review 3.  Studies on the mechanism of insulin action: basic concepts and clinical implications.

Authors:  K D Hepp
Journal:  Diabetologia       Date:  1977-05       Impact factor: 10.122

4.  Mechanism of anti-lipolytic action of acipimox in isolated rat adipocytes.

Authors:  A W Christie; D K McCormick; N Emmison; F B Kraemer; K G Alberti; S J Yeaman
Journal:  Diabetologia       Date:  1996-01       Impact factor: 10.122

5.  Comparative study of the incorporation of 32P into the phospholipids of membranes from Novikoff hepatoma ascites cells and liver cells from normal and tumor bearing animals.

Authors:  L J Anghileri
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1973-12-28

6.  A cell-contact model for cellular position determination in development.

Authors:  D McMahon
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

7.  Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin.

Authors:  M D Hollenberg; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

8.  Emergence of insulin receptors on human lymphocytes during in vitro transformation.

Authors:  U Krug; F Krug; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

9.  Insulin effect in vitro on human erythrocyte plasma membrane.

Authors:  P Luly; P Baldini; S Incerpi; E Tria
Journal:  Experientia       Date:  1981-04-15

10.  The effect of oxytetracycline on insulin resistance in obese mice.

Authors:  N Bégin-Heck; M Bourassa; H M Heick
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857
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