Literature DB >> 4332821

DNA of Rous sarcoma virus: its nature and significance.

W E Levinson, H E Varmus, A C Garapin, J M Bishop.   

Abstract

Purified preparations of Rous sarcoma virus (an avian tumor virus with an RNA genome) contain small amounts of double-stranded DNA. This DNA cannot be hybridized to viral RNA, but will reanneal completely with the DNA of avian cells. Extensive substitution of bromodeoxyuridine for thymidine in "viral" DNA does not photosensitize the biological activity of the virus. These observations indicate that the DNA associated with Rous sarcoma virus is derived from the DNA of the avian host cell, and is probably devoid of any function in the life cycle of the virus.

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Year:  1972        PMID： 4332821     DOI： 10.1126/science.175.4017.76

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Human foamy virus reverse transcription that occurs late in the viral replication cycle.

Authors:  A Moebes; J Enssle; P D Bieniasz; M Heinkelein; D Lindemann; M Bock; M O McClure; A Rethwilm
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

2.  The importance of Src signaling in sarcoma.

Authors:  Quanchi Chen; Zifei Zhou; Liancheng Shan; Hui Zeng; Yingqi Hua; Zhengdong Cai
Journal:  Oncol Lett       Date:  2015-05-06       Impact factor: 2.967

3.  Encapsulation of lymphocyte DNA by vesicular stomatitis virus.

Authors:  D T Kingsbury; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

4.  Partial reverse transcripts in virions from human immunodeficiency and murine leukemia viruses.

Authors:  D Trono
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

5.  New procedure for the direct analysis of in vitro reverse transcription of Rous sarcoma virus RNA.

Authors:  J L Darlix; P A Bromley; P F Spahr
Journal:  J Virol       Date:  1977-04       Impact factor: 5.103

6.  The plasma peptides of ovarian cancer.

Authors:  Jaimie Dufresne; Pete Bowden; Thanusi Thavarajah; Angelique Florentinus-Mefailoski; Zhuo Zhen Chen; Monika Tucholska; Tenzin Norzin; Margaret Truc Ho; Morla Phan; Nargiz Mohamed; Amir Ravandi; Eric Stanton; Arthur S Slutsky; Claudia C Dos Santos; Alexander Romaschin; John C Marshall; Christina Addison; Shawn Malone; Daren Heyland; Philip Scheltens; Joep Killestein; Charlotte E Teunissen; Eleftherios P Diamandis; K W Michael Siu; John G Marshall
Journal:  Clin Proteomics       Date:  2018-12-21       Impact factor: 3.988

7.  Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung.

Authors:  Kristin Baird; John Glod; Seth M Steinberg; Denise Reinke; Joseph G Pressey; Leo Mascarenhas; Noah Federman; Neyssa Marina; Sant Chawla; Joanne P Lagmay; John Goldberg; Mohammed Milhem; David M Loeb; James E Butrynski; Brian Turpin; Arthur Staddon; Sheri L Spunt; Robin L Jones; Eve T Rodler; Scott M Schuetze; Scott H Okuno; Lee Helman
Journal:  Sarcoma       Date:  2020-04-30
  7 in total

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