Literature DB >> 4332776

Inhibition of angiotensin I converting enzyme by venom peptides.

Y S Bakhle.   

Abstract

The synthetic analogues of three naturally occurring peptides from the venom of Bothrops jararaca have been tested as inhibitors of angiotensin converting enzyme activity in two systems. They have widely differing absolute potencies but the relative potencies are similar in the two systems. The high inhibitory potency of the nonapeptide is compatible with a non-competitive type of inhibition.

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Year:  1971        PMID： 4332776      PMCID： PMC1665952          DOI： 10.1111/j.1476-5381.1971.tb07176.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA.

Authors:  S H FERREIRA
Journal:  Br J Pharmacol Chemother       Date:  1965-02

2.  Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom.

Authors:  S H Ferreira; D C Bartelt; L J Greene
Journal:  Biochemistry       Date:  1970-06-23       Impact factor: 3.162

3.  Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme.

Authors:  S H Ferreira; L H Greene; V A Alabaster; Y S Bakhle; J R Vane
Journal:  Nature       Date:  1970-01-24       Impact factor: 49.962

4.  Metabolism of the angiotensins in isolated perfused tissues.

Authors:  Y S Bakhle; A M Reynard; J R Vane
Journal:  Nature       Date:  1969-06-07       Impact factor: 49.962

5.  Conversion of angiotensin I to angiotensin II by cell-free extracts of dog lung.

Authors:  Y S Bakhle
Journal:  Nature       Date:  1968-11-30       Impact factor: 49.962

6.  Subcellular distribution and properties of the bradykinin inactivation system in rabbit brain homogenates.

Authors:  A C Camargo; F G Graeff
Journal:  Biochem Pharmacol       Date:  1969-02       Impact factor: 5.858
  6 in total
  6 in total

1.  Conversion of angiotensin I in isolated perfused guinea-pig and rat lung.

Authors:  D K Meyer; R Liebig; M Abele; A Jobke; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

Review 2.  Converting enzyme inhibition and blood pressure regulation.

Authors:  A C Barger
Journal:  Agents Actions       Date:  1976-07

3.  Inhibition of angiotensin-coverting enzyme by analogs of peptides from Bothrops jararaca venom.

Authors:  D W Cushman; J Pluscec; N J Williams; E R Weaver; E F Sabo; O Kocy; H S Cheung; M A Ondetti
Journal:  Experientia       Date:  1973-08-15

Review 4.  The metabolic activity of pulmonary endothelial cells.

Authors:  A F Junod
Journal:  Pneumonologie       Date:  1976-06-25

5.  The inactivation of bradykinin in the pulmonary circulation of isolated lungs.

Authors:  V A Alabaster; Y S Bakhle
Journal:  Br J Pharmacol       Date:  1972-06       Impact factor: 8.739

6.  The renin-angiotensin-aldosterone system in congestive failure in conscious dogs.

Authors:  L Watkins; J A Burton; E Haber; J R Cant; F W Smith; A C Barger
Journal:  J Clin Invest       Date:  1976-06       Impact factor: 14.808
  6 in total

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