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Literature DB >> 4332628

Gamma-aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord.

Abstract

The convulsant alkaloid bicuculline blocked presynaptic inhibition, dorsal root potentials, primary afferent depolarization, and depolarizing effects of gamma-aminobutyric acid on dorsal root terminals of the amphibian spinal cord, but did not block effects of other putative amino acid transmitters. These actions of bicuculline suggest that gamma-aminobutyric acid may be the transmitter involved in spinal presynaptic inhibition.

Entities: Chemical

Mesh：

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Year: 1972 PMID： 4332628 DOI： 10.1126/science.175.4019.331

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

25 in total

1. Studies on convulsants in the isolated frog spinal cord. II. Effects on root potentials.

Authors: J L Barker; R A Nicoll; A Padjen
Journal: J Physiol Date: 1975-03 Impact factor: 5.182

Review 2. The clinical use of barbiturates in neurological disorders.

Authors: M C Smith; B J Riskin
Journal: Drugs Date: 1991-09 Impact factor: 9.546

3. Antagonism of the spinal action of diazepam by semicarbazide.

Authors: N R Banna; S J Jabbur; N E Saadé
Journal: Br J Pharmacol Date: 1974-05 Impact factor: 8.739

4. Properties and distribution of peripherally evoked presynaptic hyperpolarization in cat lumbar spinal cord.

Authors: L Mendell
Journal: J Physiol Date: 1972-11 Impact factor: 5.182

Review 5. Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture.

Authors: R L Macdonald; A B Young
Journal: Mol Cell Biochem Date: 1981-08-11 Impact factor: 3.396

Gamma-aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord.

1. Studies on convulsants in the isolated frog spinal cord. II. Effects on root potentials.

Review 2. The clinical use of barbiturates in neurological disorders.

3. Antagonism of the spinal action of diazepam by semicarbazide.

4. Properties and distribution of peripherally evoked presynaptic hyperpolarization in cat lumbar spinal cord.

Review 5. Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture.

6. Effects of GABA, glycine, and sodium barbiturate on dendritic growth in vitro.

7. The pharmacology and ionic dependency of amino acid responses in the frog spinal cord.

8. Amino acid pharmacology of mammalian central neurones grown in tissue culture.

9. Pentobarbitone pharmacology of mammalian central neurones grown in tissue culture.

10. The effect of conformationally restricted amino acid. Analogues on the frog spinal cord in vitro.