Literature DB >> 4330304

Cyclic adenosine monophosphate: function in photoreceptors.

W H Miller, R E Gorman, M W Bitensky.   

Abstract

Inactivation of adenylate cyclase in outer segments of retinal photoreceptor cells is proportional to the bleaching of rhodopsin. Membranes of the outer segments also contain a particulate, light-insensitive phosphodiesterase of high specific activity. In electrophysiological experiments, application of cyclic adenosine monophosphate along with a methylxanthine mimics the effects of illumination on the photoreceptor cell of the compound eye of Limulus.

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Year:  1971        PMID： 4330304     DOI： 10.1126/science.174.4006.295

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding.

Authors:  Lutz Birnbaumer
Journal:  Biochim Biophys Acta       Date:  2006-10-04

2.  Electron microscopic histochemical studies of cyclic 3', 5'-nucleotide phosphodiesterase in the developing retina of normal mice and mice with hereditary retinal degeneration.

Authors:  R M Robb
Journal:  Trans Am Ophthalmol Soc       Date:  1974

3.  Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments.

Authors:  K Nakano; J Chen; G E Tarr; T Yoshida; J M Flynn; M W Bitensky
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-03       Impact factor: 11.205

4.  Stimulation by dopamine of adenylate cyclase in retinal homogenates and of adenosine-3':5'-cyclic monophosphate formation in intact retina.

Authors:  J H Brown; M H Makman
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205

5.  Regulation of cyclic nucleotide concentrations in photoreceptors: an ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light.

Authors:  N Miki; J J Keirns; F R Marcus; J Freeman; M W Bitensky
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

6.  3',5'-cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.

Authors:  J E Brown; U B Kaupp; C C Malbon
Journal:  J Physiol       Date:  1984-08       Impact factor: 5.182

7.  Cyclic-nucleotide phosphodiesterase: an early defect in inherited retinal degeneration of C3H mice.

Authors:  S Y Schmidt; R N Lolley
Journal:  J Cell Biol       Date:  1973-04       Impact factor: 10.539
  7 in total

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