| Literature DB >> 4329969 |
M N Oxman, A S Levine, C S Crumpacker, M J Levin, P H Henry, A M Lewis.
Abstract
Ad2(+)ND(1), a nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, has been previously shown to contain a small segment of the SV40 genome covalently linked to Ad2 deoxyribonucleic acid (DNA). The SV40 portion of this hybrid virus has been characterized by relating the SV40-specific ribonucleic acid (RNA) sequences transcribed from the Ad2(+)ND(1) DNA to those transcribed from the DNA of SV40 itself. RNA-DNA hybridization-competition studies indicate that the SV40 component of Ad2(+)ND(1) consists of some, but not all, of that part of the SV40 genome which is transcribed early, i.e., prior to viral DNA replication, in SV40 lytic infection.Entities:
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Year: 1971 PMID: 4329969 PMCID: PMC356233
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103