Literature DB >> 432642

Induction of copulatory behavior in sexually inactive rats by naloxine.

G L Gessa, E Paglietti, B P Quarantotti.   

Abstract

The intraventricular injection of D-alanine-methionine-enkephalinamide (D-Ala2-Met-enkephalinamide), a synthetic analog of Met-enkephalin that is resistant to enzymatic degradation, inhibits copulatory behavior in sexually vigorous male rats in doses which do not influence motor activity or feeding behavior. This effect is prevented by naloxone, a specific inhibitor of opioid receptors. In addition, injections of naloxone induce copulatory behavior in sexually inactive male rats. These results suggest that endorphins play an important role in the regulation of sexual behavior.

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Year:  1979        PMID： 432642     DOI： 10.1126/science.432642

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

Review 1.  Opioid peptides in the testis and the male genital tract: presence and possible function.

Authors:  A Fabbri; F Fraioli; A Isidori
Journal:  J Endocrinol Invest       Date:  1986-12       Impact factor: 4.256

2.  The 24-hour secretory pattern of LH and the response to LHRH in transsexual men.

Authors:  R M Boyar; J Aiman
Journal:  Arch Sex Behav       Date:  1982-04

3.  Reinforcement with naloxone of N-n-propylnorapomorphine (NPA) capability for stimulating male rat copulatory behavior.

Authors:  F Ferrari; G Baggio
Journal:  Experientia       Date:  1982-08-15

Review 4.  Retarded ejaculation in men: an overview of psychological and neurobiological insights.

Authors:  Marcel D Waldinger; Dave H Schweitzer
Journal:  World J Urol       Date:  2005-06-04       Impact factor: 4.226

5.  Perinatal ethanol exposure alters met-enkephalin levels of male and female rats.

Authors:  Joaquin N Lugo; Marlene A Wilson; Sandra J Kelly
Journal:  Neurotoxicol Teratol       Date:  2006-02-02       Impact factor: 3.763

6.  Effects of opiate antagonists on hormones and behavior of male and female rhesus monkeys.

Authors:  D H Abbott; S D Holman; M Berman; D A Neff; R W Goy
Journal:  Arch Sex Behav       Date:  1984-02

Review 7.  The effects of opioids and opioid analogs on animal and human endocrine systems.

Authors:  Cassidy Vuong; Stan H M Van Uum; Laura E O'Dell; Kabirullah Lutfy; Theodore C Friedman
Journal:  Endocr Rev       Date:  2009-11-10       Impact factor: 19.871

8.  Naloxone disrupts the expression but not the acquisition by male rats of a conditioned place preference response for an oestrous female.

Authors:  B J Mehrara; M J Baum
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

9.  Threshold differences for naloxone and naltrexone in the hypothalamus and midbrain using fixed ratio brain self-stimulation in rats.

Authors:  G J Schaefer; R P Michael
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

10.  Bilateral injections of a selective mu-receptor agonist (morphiceptin) into the medial preoptic nucleus produces a marked delay in the initiation of sexual behavior in the male rat.

Authors:  L Matuszewich; W A Dornan
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530
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