Literature DB >> 432639

Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures.

M Karin, H R Herschman.   

Abstract

HeLa cells in culture synthesize metallothionein. To investigate the effects of glucocorticoids on metallothionein synthesis we adapted HeLa cells to growth in a defined medium lacking hydrocortisone. In this defined medium, containing 1.5 x 10(-6)M Zn2+, dexamethasone (10(-6)M) caused a five- to sixfold increase in the synthesis of metallothionein. Progesterone (10(-5)M), a known antagonist of glucocorticoids, inhibited this response by 50 percent.

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Year:  1979        PMID： 432639     DOI： 10.1126/science.432639

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  A human metallothionein pseudogene containing AG/CT repetitive elements.

Authors:  J M Walker; L Gedamu
Journal:  J Mol Evol       Date:  1990-09       Impact factor: 2.395

2.  Profile of Michael Karin.

Authors:  Tinsley H Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-14       Impact factor: 11.205

3.  Influence of haemodialysis and renal transplantation on trace element concentrations in children with chronic renal failure.

Authors:  M Wihelm; B Hanewinckel; F Bläker
Journal:  Eur J Pediatr       Date:  1986-10       Impact factor: 3.183

4.  Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

Authors:  D M Durnam; J S Hoffman; C J Quaife; E P Benditt; H Y Chen; R L Brinster; R D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

5.  Human metallothionein genes are clustered on chromosome 16.

Authors:  M Karin; R L Eddy; W M Henry; L L Haley; M G Byers; T B Shows
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

6.  Purified glucocorticoid receptor-hormone complex from rat liver cytosol binds specifically to cloned mouse mammary tumor virus long terminal repeats in vitro.

Authors:  M V Govindan; E Spiess; J Majors
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

7.  Hepatic metallothionein synthesis in neonatal Mottled-Brindled mutant mice.

Authors:  J E Piletz; H R Herschman
Journal:  Biochem Genet       Date:  1983-06       Impact factor: 1.890

8.  Induction of metallothionein by zinc in lethal milk mutant mice.

Authors:  J E Piletz; H R Herschman
Journal:  Biochem Genet       Date:  1982-12       Impact factor: 1.890

9.  Effect of adrenalectomy on cadmium- and turpentine-induced hepatic synthesis of metallothionein and alpha 2-macrofetoprotein in the rat.

Authors:  P Z Sobocinski; W J Canterbury; G L Knutsen; E C Hauer
Journal:  Inflammation       Date:  1981-06       Impact factor: 4.092

10.  Antagonism of cadmium cytotoxicity by differentiation inducers.

Authors:  C Shopsis
Journal:  Cell Biol Toxicol       Date:  1994-06       Impact factor: 6.691
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