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Literature DB >> 4323933

Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog.

Abstract

1. End-plate potentials were recorded intracellularly at the frog neuromuscular junction bathed in a solution containing a low concentration of calcium and a high concentration of magnesium.2. The muscle was subsequently subjected to ;cholinesterase staining', and the area of the individual end-plates, studied with intracellular electrodes, was measured.3. A positive correlation was found between the end-plate area and the diameter of muscle fibres.4. The mean quantum content (m) showed a positive correlation with the size of end-plates.5. The frequency of spontaneous miniature end-plate potentials was positively correlated with m as well as with end-plate area.6. It is concluded that the amount of transmitter released following nerve stimulation is related to the size of nerve endings.

Entities: Chemical Gene

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Year: 1971 PMID： 4323933 PMCID： PMC1331740 DOI： 10.1113/jphysiol.1971.sp009399

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

26 in total

Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog.

1. The mechanism of synaptic transmission.

2. Further analysis of relationship between end-plate potential and end-plate current.

3. The fine structure of the neuromuscular junction of the frog.

4. On the factors which determine the amplitude of the miniature end-plate potential.

5. Structural variations of nerve endings in the striated muscles of the rat.

6. Mononeuronal double innervation of an amphibian striated muscle fibre.

7. Neuromuscular facilitation by stretch of motor nerve-endings.

8. The morphology of the myoneural junction as influenced by neurotoxic drugs.

9. Spontaneous subthreshold activity at motor nerve endings.

10. Effect of barbiturates on 'quantal' synaptic transmission in spinal motoneurones.

1. Disparity in neurotransmitter release probability among competing inputs during neuromuscular synapse elimination.

2. Voltage dependence of agonist effectiveness at the frog neuromuscular junction: resolution of a paradox.

3. The effect of calcium ions on the secretion of quanta evoked by an impulse at nerve terminal release sites.

4. Physiological properties of junctions between nerve and muscle developing during salamander limb regeneration.

5. Regulation of single quantal efficacy at the snake neuromuscular junction.

6. Postnatal development of rat motor nerve terminals.

7. Anabolic effect of testosterone on the levator ani muscle of the rat.

8. Effect of alpha-latrotoxin on the frog neuromuscular junction at low temperature.

9. Early induction by crotoxin of biphasic frequency changes and giant miniature endplate potentials in frog muscle.

10. Electrical excitability of motor nerve terminals in the mouse.