Literature DB >> 4323795

Immunoglobulin production by human lymphocytoid lines and clones: absence of genic exclusion.

A D Bloom, K W Choi, B J Lamb.   

Abstract

Immunoglobulin production was studied in established lines of normal human lymphocytes. Three lines which produced both immunoglobulin G and immunoglobulin M were cloned. Among the 25 immunoglobulin-producing clones, 23 produced both classes of immunoglobulins. These findings suggest that the phenomenon of genic exclusion does not hold for immunoglobulin production in lymphocytoid cells in culture.

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Year:  1971        PMID： 4323795     DOI： 10.1126/science.172.3981.382

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  5 in total

1.  Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes in culture.

Authors:  B Mitchell; E Haigis; B Steinmann; R Gitzelmann
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

2.  Establishment of a tetraploid, immunoglobulin-producing cell line from the hybridization of two human lymphocyte lines.

Authors:  A D Bloom; F T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205

3.  Synthesis of plasma membrane-associated and secretory immunoglobulin in diploid lymphocytes.

Authors:  R A Lerner; P J McConahey; I Jansen; F J Dixon
Journal:  J Exp Med       Date:  1972-01       Impact factor: 14.307

4.  Somatic hybridization as a tool for the study of differentiation: a review.

Authors:  M Nabholz
Journal:  Biochem J       Date:  1971-10       Impact factor: 3.857

5.  Lambda-chain production in human lymphoblast-mouse fibroblast hybrids.

Authors:  S H Orkin; P D Buchanan; W J Yount; H Reisner; J W Littlefield
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205
  5 in total

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