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Literature DB >> 4323790

Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine.

Abstract

A biologically active vitamin D(3) metabolite ("peak V metabolite") more polar than 25-hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono(trimethylsilyl)ether derivative. The molecule has been identified as 1,25-dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption spectrophotometry, and specific chemical reactions.

Entities: Chemical Species

Mesh：

Substances：

Year: 1971 PMID： 4323790 PMCID： PMC389047 DOI： 10.1073/pnas.68.4.803

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

13 in total

1. 21,25-dihydroxycholecalciferol. A metabolite of vitamin D3 preferentially active on bone.

Authors: T Suda; H F DeLuca; H K Schnoes; G Ponchon; Y Tanaka; M F Holick
Journal: Biochemistry Date: 1970-07-07 Impact factor: 3.162

2. Metabolites of vitamin D3 and their biologic activity.

Authors: G Ponchon; H F Deluca
Journal: J Nutr Date: 1969-10 Impact factor: 4.798

3. Metabolism and subcellular location of 25-hydroxycholecalciferol in intestinal mucosa.

Authors: R J Cousins; H F DeLuca; T Chen; T Suda; Y Tanaka
Journal: Biochemistry Date: 1970-03-17 Impact factor: 3.162

4. 25,26-dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activity.

Authors: H F DeLuca; T Suda; H K Schnoes; Y Tanaka; M F Holick
Journal: Biochemistry Date: 1970-11-24 Impact factor: 3.162

5. Metabolism of vitamin D. A new cholecalciferol metabolite, involving loss of hydrogen at C-1, in chick intestinal nuclei.

Authors: D E Lawson; P W Wilson; E Kodicek
Journal: Biochem J Date: 1969-11 Impact factor: 3.857

6. Biological activity of 25-hydroxycholecalciferol, a metabolite of vitamin D3.

Authors: J W Blunt; Y Tanaka; H F DeLuca
Journal: Proc Natl Acad Sci U S A Date: 1968-12 Impact factor: 11.205

7. 25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3.

Authors: J W Blunt; H F DeLuca; H K Schnoes
Journal: Biochemistry Date: 1968-10 Impact factor: 3.162

8. The isolation and identification of 25-hydroxyergocalciferol.

Authors: T Suda; H F DeLuca; H K Schnoes; J W Blunt
Journal: Biochemistry Date: 1969-09 Impact factor: 3.162

9. The association of a metabolite of vitamin D3 with intestinal mucosa chromatin in vivo.

Authors: M R Haussler; J F Myrtle; A W Norman
Journal: J Biol Chem Date: 1968-08-10 Impact factor: 5.157

10. Biologically active metabolite of vitamin D3 from bone, liver, and blood serum.

Authors: J Lund; H F DeLuca
Journal: J Lipid Res Date: 1966-11 Impact factor: 5.922

50 in total

1. Complementary and alternative medicine for the treatment of multiple sclerosis.

Authors: Vijayshree Yadav; Lynne Shinto; Dennis Bourdette
Journal: Expert Rev Clin Immunol Date: 2010-05 Impact factor: 4.473

2. UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production.

Authors: Bryan R Becklund; Kyle S Severson; Souriya V Vang; Hector F DeLuca
Journal: Proc Natl Acad Sci U S A Date: 2010-03-22 Impact factor: 11.205

Review 3. Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians.

Authors: Giuseppe Saggese; Francesco Vierucci; Flavia Prodam; Fabio Cardinale; Irene Cetin; Elena Chiappini; Gian Luigi De' Angelis; Maddalena Massari; Emanuele Miraglia Del Giudice; Michele Miraglia Del Giudice; Diego Peroni; Luigi Terracciano; Rino Agostiniani; Domenico Careddu; Daniele Giovanni Ghiglioni; Gianni Bona; Giuseppe Di Mauro; Giovanni Corsello
Journal: Ital J Pediatr Date: 2018-05-08 Impact factor: 2.638

4. 25-Hydroxyvitamin D3 regulation.

Authors: M B Clark; J T Potts
Journal: Calcif Tissue Res Date: 1977-05

5. Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor.

Authors: Yanping Wang; Steven J Marling; Jinge G Zhu; Kyle S Severson; Hector F DeLuca
Journal: Proc Natl Acad Sci U S A Date: 2012-05-16 Impact factor: 11.205

Review 6. Clinical review: The role of the parent compound vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes.

Authors: Bruce W Hollis; Carol L Wagner
Journal: J Clin Endocrinol Metab Date: 2013-10-08 Impact factor: 5.958