| Literature DB >> 4323251 |
W K Ashe, C A Daniels, G S Scott, A L Notkins.
Abstract
Rheumatoid factor, a human immunoglobulin of the IgM class, failed to attach to herpes simplex virus but did attach to infectious complexes composed of herpes simplex virus and antibody to herpes simplex virus. These newly formed complexes of infectious virus, antiviral antibody, and rheumatoid factor could be neutralized by complement or by antibody to human IgM. The ability of rheumatoid factor to enhance virus neutralization in the presence of complement represents a hitherto unrecognized biological role for rheumatoid factor.Entities:
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Year: 1971 PMID: 4323251 DOI: 10.1126/science.172.3979.176
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728