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Literature DB >> 4322522

Adenyl cyclase as a link between photon capture and changes in membrane permeability of frog photoreceptors.

Abstract

Tomita has shown by electrophysiological measurements that the photoreceptors of the vertebrate retina are depolarized (excited) by darkness and hyperpolarized (inhibited) by light. Excitation is accompanied by an increase, and inhibition by a decrease, in the sodiumion permeability of the receptor cell. The retinal-rod outer segments of the frog contain an adenyl cyclase that is active in darkness and inactivated by light. This cyclase has a specific activity ten-times higher than the activity in previously described tissues. It is suggested that cyclic AMP is an intermediate in the light- and dark-induced changes in sodium permeability in the photoreceptor cell.

Entities: Chemical Gene

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Year: 1971 PMID： 4322522 PMCID： PMC388988 DOI： 10.1073/pnas.68.3.561

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

10 in total

1. Studies on visual cell viability and differentiation.

Authors: W K NOELL
Journal: Ann N Y Acad Sci Date: 1959-11-12 Impact factor: 5.691

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. Independent variation of glucagon and epinephrine responsive components of hepatic adenyl cyclase as a function of age, sex and steroid hormones.

Authors: M W Bitensky; V Russell; M Blanco
Journal: Endocrinology Date: 1970-01 Impact factor: 4.736

4. Inhibitory effects of alloxan on mammalian adenyl cyclase.

Authors: K L Cohen; M W Bitensky
Journal: J Pharmacol Exp Ther Date: 1969-09 Impact factor: 4.030

5. Molecular basis of visual excitation.

Authors: G Wald
Journal: Science Date: 1968-10-11 Impact factor: 47.728

6. Studies on the mass receptor potential of the isolated frog retina. II. On the basis of the ionic mechanism.

Authors: A J Sillman; H Ito; T Tomita
Journal: Vision Res Date: 1969-12 Impact factor: 1.886

7. Evidence for separate epinephrine and glucagon responsive adenyl cyclase systems in rat liver.

Authors: M W Bitensky; V Russell; W Robertson
Journal: Biochem Biophys Res Commun Date: 1968-06-10 Impact factor: 3.575

8. Effects of active sodium transport on current-voltage relationship of toad bladder.

Authors: M M Civan
Journal: Am J Physiol Date: 1970-07

9. Visual receptors and retinal interaction.

Authors: H K Hartline
Journal: Science Date: 1969-04-18 Impact factor: 47.728

Review 10. Electrical activity of vertebrate photoreceptors.

Authors: T Tomita
Journal: Q Rev Biophys Date: 1970-05 Impact factor: 5.318

10 in total

25 in total

1. Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin.

Authors: M Weller; N Virmaux; P Mandel
Journal: Proc Natl Acad Sci U S A Date: 1975-01 Impact factor: 11.205

2. The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding.

Authors: Lutz Birnbaumer
Journal: Biochim Biophys Acta Date: 2006-10-04

Adenyl cyclase as a link between photon capture and changes in membrane permeability of frog photoreceptors.

1. Studies on visual cell viability and differentiation.

2. Protein measurement with the Folin phenol reagent.

3. Independent variation of glucagon and epinephrine responsive components of hepatic adenyl cyclase as a function of age, sex and steroid hormones.

4. Inhibitory effects of alloxan on mammalian adenyl cyclase.

5. Molecular basis of visual excitation.

6. Studies on the mass receptor potential of the isolated frog retina. II. On the basis of the ionic mechanism.

7. Evidence for separate epinephrine and glucagon responsive adenyl cyclase systems in rat liver.

8. Effects of active sodium transport on current-voltage relationship of toad bladder.

9. Visual receptors and retinal interaction.

Review 10. Electrical activity of vertebrate photoreceptors.

1. Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin.

2. The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding.

3. Evidence against an involvement of cyclic nucleotides in the induction of betacyanin synthesis by cytokinins.

4. On a soluble system for studying light activation of rod outer segment cyclic GMP phosphodiesterase.

5. A light-activated GTPase in vertebrate photoreceptors: regulation of light-activated cyclic GMP phosphodiesterase.

Review 6. Cyclic nucleotides and retinal cones.

7. Cyclic GMP injected into retinal rod outer segments increases latency and amplitude of response to illumination.

8. Opsin exhibits cGMP-activated single-channel activity.

9. Rapid Phytochrome-mediated Changes in Adenosine 5'-Triphosphate Content of Etiolated Bean Buds.

10. Extraction, purification and identification of cytidine 3',5'-cyclic monophosphate from rat tissues.