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Literature DB >> 4322025

A specific competitive inhibitor of angiotensin II.

Abstract

A peptide analog, [4-phenylalanine, 8-tyrosine]-angiotensin II, was prepared by solid phase peptide synthesis and its structure confirmed. The compound was found to be a potent inhibitor of angiotensin II in vitro (isolated rat uterus strips) and in vivo (rat blood pressure). The analog was found to be highly specific and did not inhibit the action of a number of other peptides and spasmogenic compounds.

Entities: Gene Species

Mesh：

Substances：
Peptides
Angiotensin II

Year: 1970 PMID： 4322025 PMCID： PMC283399 DOI： 10.1073/pnas.67.3.1624

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

13 in total

1. Use of hydrogen fluoride in Merrifield solid-phase peptide synthesis.

Authors: J Lenard; A B Robinson
Journal: J Am Chem Soc Date: 1967-01-04 Impact factor: 15.419

2. Analogs of angiotensin II. II. Mechanism of receptor interaction.

Authors: P A Khairallah; A Toth; F M Bumpus
Journal: J Med Chem Date: 1970-03 Impact factor: 7.446

3. Inhibition of norepinephrine uptake in hearts by angiotensin II and analogs.

Authors: M J Peach; F M Bumpus; P A Khairallah
Journal: J Pharmacol Exp Ther Date: 1969-06 Impact factor: 4.030

4. Angiotensin II analogs. II. Cyclo-(-Val-Tyr-Ile-His-Pro-Phe-).

Authors: E C Jorgensen; W Patton
Journal: J Med Chem Date: 1969-09 Impact factor: 7.446

5. Tritiated angiotensin: preparation and purification.

Authors: R R Smeby; P A Khairallah; F M Bumpus
Journal: Nature Date: 1966-09-10 Impact factor: 49.962

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Authors: K Vogler; R O Studer; W Lergier; P Lanz
Journal: Helv Chim Acta Date: 1965-09-20 Impact factor: 2.164

7. Immunochemical studies on the poly-gamma-D-glutamyl capsule of Bacillus anthracis. I. Characterization of the polypeptide and of the specificity of its reaction with rabbit antisera.

Authors: J W Goodman; D E Nitecki
Journal: Biochemistry Date: 1966-02 Impact factor: 3.162

8. Cleavage of single amino acid residues from Merrifield resin with hydrogen chloride and hydrogen fluoride.

Authors: J Scotchler; R Lozier; A B Robinson
Journal: J Org Chem Date: 1970-09 Impact factor: 4.354

9. All-D-bradykinin and the problem of peptide antimetabolites.

Authors: J M Stewart; D W Woolley
Journal: Nature Date: 1965-05-08 Impact factor: 49.962

10. [8-Arginine]-vasopressinoic acid: an inhibitor of rabbit kidney adenyl cyclase.

Authors: T Dousa; O Hechter; R Walter; I L Schwartz
Journal: Science Date: 1970-02-20 Impact factor: 47.728

12 in total

1. Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action.

Authors: Y J Liu; N P Shankley; N J Welsh; J W Black
Journal: Br J Pharmacol Date: 1992-06 Impact factor: 8.739

2. A comparative study of two structurally related analogs of Asp1-Ile5-angiotensin II.

Authors: R K Türker; N U Gündoğan
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1974 Impact factor: 3.000

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Authors: F Gross
Journal: Klin Wochenschr Date: 1972-07-01

4. Specific inhibitors for angiotensin II and angiotensin I.

Authors: W K Park; D Regoli
Journal: Br J Pharmacol Date: 1971-10 Impact factor: 8.739

5. 2-Naphthalenesulphonyl L-aspartyl-(2-phenethyl)amide (2-NAP)--a selective cholecystokinin CCKA-receptor antagonist.

Authors: R A Hull; N P Shankley; E A Harper; V P Gerkowitch; J W Black
Journal: Br J Pharmacol Date: 1993-03 Impact factor: 8.739

6. Selective inhibition of angiotensin pressor responses in the pithed rat by tetraethylthiuram disulphide (disulfiram) and sodium diethyldithiocarbamate (DDC).

Authors: M D Day; J M Hall; D A Owen
Journal: Br J Pharmacol Date: 1972-02 Impact factor: 8.739