Effects of adenosine 3',5'-monophosphate on renal function in the rabbit.

1. Intravenous injections of adenosine 3',5'-monophosphate (cyclic-AMP) were given to five conscious, diuretic rabbits, and the effects on urinary flow and composition were compared with those of intravenous injections of vasopressin given to the same animals.2. Cyclic-AMP produced antidiuresis with increases in urinary osmolality and in the urinary concentrations of creatinine, urea and usually of sodium.3. The fractional reabsorption of urea from renal tubular fluid increased during cyclic-AMP induced antidiuresis.4. The effects of cyclic-AMP thus closely resembled those of vasopressin and are consistent with the view that cyclic-AMP mediates the action of this hormone.