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Literature DB >> 4320974

Behavior of tissue culture cells infected with polyoma virus.

Abstract

Infection of tissue culture cells with the oncogenic polyoma virus, or its temperature-sensitive mutant Ts-a, causes several changes other than the previously known induction of cellular DNA synthesis. Cellular movement, survival, and mitotic rate are enhanced in low-serum medium, and morphology is changed; the cellular growth parameters, wound serum requirement, and topoinhibition are markedly decreased. The changes are similar to those that occur in cell transformation and are produced by viral functions known to be expressed in transformed cells. Clues as to the possible mechanisms of all these changes are analyzed and a possible mechanism is discussed.

Entities: Disease

Mesh：

Year: 1970 PMID： 4320974 PMCID： PMC283339 DOI： 10.1073/pnas.67.3.1214

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

17 in total

2. A polyoma mutant that encodes small T antigen but not middle T antigen demonstrates uncoupling of cell surface and cytoskeletal changes associated with cell transformation.

Authors: T J Liang; G G Carmichael; T L Benjamin
Journal: Mol Cell Biol Date: 1984-12 Impact factor: 4.272

3. Nonproductive infection and induction of cellular deoxyribonucleic acid synthesis by bovine adenovirus type 3 in a contact-inhibited mouse cell line.

Authors: K Tsukamoto; Y Sugino
Journal: J Virol Date: 1972-03 Impact factor: 5.103

4. The effects of various mammalian sera on attachment efficiency and thymidine incorporation in primary cultures of mouse mammary epithelial cells.

Authors: M K Feldman; D L Wong
Journal: In Vitro Date: 1977-05

4 in total

Behavior of tissue culture cells infected with polyoma virus.

1. Regulation of transcription of the SV40 DNA in productively infected and in transformed cells.

2. Control of DNA synthesis in cells infected with polyoma virus.

3. Properties of clonal lines of murine sarcoma virus transformed Balb-3T3 cells.

4. Replication of polyoma virus DNA. I. A resting cell system for biochemical studies on polyoma virus.

5. Selective extraction of polyoma DNA from infected mouse cell cultures.

6. Induction of DNA synthesis by SV40.

7. Characterization of the simian virus 40-specific RNA in virus-yielding and transformed cells.

8. Abortive transformation by polyoma virus.

9. Synthesis and transmethylation of DNA in polyoma-infected cultures.

10. Induction of cellular DNA synthesis by polyoma virus.

1. Temperature-dependent properties of cells transformed by a thermosensitive mutant of polyoma virus.

2. A polyoma mutant that encodes small T antigen but not middle T antigen demonstrates uncoupling of cell surface and cytoskeletal changes associated with cell transformation.

3. Nonproductive infection and induction of cellular deoxyribonucleic acid synthesis by bovine adenovirus type 3 in a contact-inhibited mouse cell line.

4. The effects of various mammalian sera on attachment efficiency and thymidine incorporation in primary cultures of mouse mammary epithelial cells.