Specificity of action of adrenocorticotrophin in vitro on ascorbate transport in rat adrenal glands.

The inhibition of ascorbate transport by rat adrenal quarters in response to steroidogenesis in vitro was shown to be highly specific with respect to tissue, substrate and steroidogenic agent. The transport system in vitro is capable of net accumulation of ascorbate. The evidence is consistent with the conclusion that ascorbate ;depletion' in the adrenal gland is due to a specific block by corticoids of the uptake of ascorbate.