Literature DB >> 4318785

DNA and gene therapy: uncoating of polyoma pseudovirus in mouse embryo cells.

J V Osterman, A Waddell, H V Aposhian.   

Abstract

Pseudovirions (host DNA fragments encapsidated by polyoma virus-coat protein) and polyoma virions are produced after infection of primary mouse embryo cells with polyoma virus. Purified pseudovirions are adsorbed to, and uncoated by, mouse embryo cells. The evidence for this uncoating is based on the conversion by pancreatic DNase of the uncoated pseudovirus DNA from an acid-insoluble to an acid-soluble form. The implications of these experiments to the eventual use of DNA for gene therapy are discussed.

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Year:  1970        PMID： 4318785      PMCID： PMC283162          DOI： 10.1073/pnas.67.1.37

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  THE FATE OF POLYOMA VIRUS IN HAMSTER, MOUSE, AND HUMAN CELLS.

Authors:  P BOURGAUX
Journal:  Virology       Date:  1964-05       Impact factor: 3.616

2.  The physical characteristics of polyoma virus. I. Two types of particle.

Authors:  L V CRAWFORD; E M CRAWFORD
Journal:  Virology       Date:  1962-10       Impact factor: 3.616

3.  Multiplication of Polyoma Virus I. Use of Selectively Labeled (H) Virus to Follow the Course of Infection.

Authors:  G P Khare; R A Consigli
Journal:  J Bacteriol       Date:  1965-09       Impact factor: 3.490

4.  Encapsidation of free host DNA by simian virus 40: a simian virus 40 pseudovirus.

Authors:  D M Trilling; D Axelrod
Journal:  Science       Date:  1970-04-10       Impact factor: 47.728

5.  Further studies on the incorporation of cell DNA into polyoma-related particles.

Authors:  E Winocour
Journal:  Virology       Date:  1968-04       Impact factor: 3.616

6.  Mouse cellular DNA enclosed in polyoma viral capsids (pseudovirions).

Authors:  M R Michel; B Hirt; R Weil
Journal:  Proc Natl Acad Sci U S A       Date:  1967-10       Impact factor: 11.205

7.  Failure to detect incorporation of host cell DNA into virions of adenovirus type 12.

Authors:  H zur Hausen
Journal:  Virology       Date:  1969-05       Impact factor: 3.616

8.  Molecular biology, nucleic acids, and the future of medicine.

Authors:  E L Tatum
Journal:  Perspect Biol Med       Date:  1966       Impact factor: 1.416

9.  Deoxyribonucleic acid replication in simian virus 40-infected cells. II. Detection and characterization of simian virus 40 pseudovirions.

Authors:  A J Levine; A K Teresky
Journal:  J Virol       Date:  1970-04       Impact factor: 5.103

10.  Plaque formation and isolation of pure lines with poliomyelitis viruses.

Authors:  R DULBECCO; M VOGT
Journal:  J Exp Med       Date:  1954-02       Impact factor: 14.307
  10 in total
  13 in total

1.  Formation of nucleoprotein complexes between polyoma empty capsides and DNA.

Authors:  H V Aposhian; R E Thayer; P K Qasba
Journal:  J Virol       Date:  1975-03       Impact factor: 5.103

Review 2.  Current status and prospects of gene therapy for the inner ear.

Authors:  Hong Sun; Aji Huang; Shousong Cao
Journal:  Hum Gene Ther       Date:  2011-05-19       Impact factor: 5.695

3.  Preparation of virus-like particles of DNA-IgG.

Authors:  G Carvajal; I Baeza; E J Carvajal
Journal:  Experientia       Date:  1973-10-15

4.  Polyoma pseudovirions. II. Influence of host cell on pseudovirus production.

Authors:  D B Yelton; H V Aposhian
Journal:  J Virol       Date:  1973-11       Impact factor: 5.103

5.  Polyoma pseudovirions. I. Sequence of events in primary mouse embryo cells leading to pseudovirus production.

Authors:  D B Yelton; H V Aposhian
Journal:  J Virol       Date:  1972-09       Impact factor: 5.103

6.  DNA and gene therapy: transfer of mouse DNA to human and mouse embryonic cells by polyoma pseudovirions.

Authors:  P K Qasba; H V Aposhian
Journal:  Proc Natl Acad Sci U S A       Date:  1971-10       Impact factor: 11.205

7.  Degradation of pseudoviral DNA after infection of mouse cells with polyoma pseudovirions.

Authors:  S V Kashmiri; H V Aposhian
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

Review 8.  Biotechnology in the treatment of sensorineural hearing loss: foundations and future of hair cell regeneration.

Authors:  Mark A Parker
Journal:  J Speech Lang Hear Res       Date:  2011-03-08       Impact factor: 2.297

Review 9.  Gene therapy for the inner ear: challenges and promises.

Authors:  Allen F Ryan; Stefan Dazert
Journal:  Adv Otorhinolaryngol       Date:  2009-06-02

10.  Infectious linear DNA sequences replicating in simian virus 40-infected cells.

Authors:  P Gruss; G Sauer
Journal:  J Virol       Date:  1977-02       Impact factor: 5.103
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