Literature DB >> 4318572

Microbial transformation of 19-hydroxypregnanes.

K Singh, D J Marshall, C Vézina.   

Abstract

Nocardia species aromatized 19-hydroxyprogesterone, 3beta, 19-dihydroxy-pregn-5-en-20-one 3-acetate and pregn-5-ene-3beta, 19, 20beta-triol 3-acetate, without cleavage of the side chain, into 3-hydroxy-19-norpregna-1,3,5 (10)-trien-20-one. Septomyxa affinis aromatized the ring A and cleaved the side chain of 19-hydroxyprogesterone to yield estrone. With 19-hydroxypregna-4, 7-diene-3, 20-dione as substrate, the transformation was more complex and many products were formed.

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Year:  1970        PMID： 4318572      PMCID： PMC376859          DOI： 10.1128/am.20.1.23-25.1970

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  4 in total

1.  MECHANISMS OF STEROID OXIDATION BY MICROORGANISMS. III. ENZYMATIC MECHANISM OF RING A AROMATIZATION.

Authors:  C J SIH; A M RAHIM
Journal:  J Pharm Sci       Date:  1963-11       Impact factor: 3.534

2.  A NEW ROUTE TO ESTRONE FROM STEROLS.

Authors:  C J SIH; K C WANG
Journal:  J Am Chem Soc       Date:  1965-03-20       Impact factor: 15.419

3.  A microbiological synthesis of equilin from 19-hydroxycholesta-4,7-dien-3-one.

Authors:  R Deghenghi; S Rakhit; K Singh; C Vézina
Journal:  Steroids       Date:  1967-09       Impact factor: 2.668

4.  Transformation of steroids by spores of microorganisms. I. Hydroxylation of progesterone by conidia of Aspergillus ochraceus.

Authors:  C VEZINA; S N SEHGAL; K SINGH
Journal:  Appl Microbiol       Date:  1963-01
  4 in total

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