Literature DB >> 431802

Effect of clozapine on apomorphine-induced growth hormone secretion and serum prolactin concentrations in schizophrenia.

N P Nair, S Lal, P Cervantes, R Yassa, H Guyda.   

Abstract

Clozapine had no effect on basal serum growth hormone concentrations in 10 schizophrenic patients but significantly inhibited the apomorphine-induced growth hormone increase that occurred in 7 subjects. Clozapine caused a slight (17%) but significant elevation in basal serum prolactin levels. These data suggest that in man clozapine, like other neuroleptics, blocks dopamine receptors, at least in the hypothalamic-pituitary axis.

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Year:  1979        PMID： 431802     DOI： 10.1159/000117675

Source DB:  PubMed          Journal:  Neuropsychobiology        ISSN： 0302-282X            Impact factor:   2.328


  12 in total

1.  Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment.

Authors:  Jose de Leon; Francisco J Diaz; Richard C Josiassen; George M Simpson
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2004-10       Impact factor: 5.270

Review 2.  Predictors and markers of clozapine response.

Authors:  Carmen Chung; Gary Remington
Journal:  Psychopharmacology (Berl)       Date:  2005-02-17       Impact factor: 4.530

Review 3.  Drug-induced changes in prolactin secretion. Clinical implications.

Authors:  K Hell; H Wernze
Journal:  Med Toxicol Adverse Drug Exp       Date:  1988 Nov-Dec

4.  Hypothalamic-pituitary dopaminergic function in hepatic failure in man.

Authors:  S Lal; M Oravec; A Aronoff; M E Kiely; H Guyda; S Solomon; N P Nair
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

Review 5.  Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia.

Authors:  A Fitton; R C Heel
Journal:  Drugs       Date:  1990-11       Impact factor: 9.546

6.  Stereospecificity of the dopamine receptor mediating the growth hormone response to apomorphine in man. Short communication.

Authors:  S Lal; N P Nair; J X Thavundayil; V Tawar; R Quirion; H Guyda
Journal:  J Neural Transm Gen Sect       Date:  1991

Review 7.  Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications.

Authors:  E E Müller; V Locatelli; S Cella; A Peñalva; A Novelli; D Cocchi
Journal:  Drugs       Date:  1983-04       Impact factor: 9.546

8.  Clozapine: plasma levels and prolactin response.

Authors:  J M Kane; T B Cooper; E J Sachar; F S Halpern; S Bailine
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

Review 9.  Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia.

Authors:  H Y Meltzer
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

10.  Effect of sleep deprivation on dopamine receptor function in normal subjects.

Authors:  S Lal; J Thavundayil; N P Nair; P Etienne; R Rastogi; G Schwartz; J Pulman; H Guyda
Journal:  J Neural Transm       Date:  1981       Impact factor: 3.575
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