| Literature DB >> 4317401 |
F A Kuehl, J L Humes, J Tarnoff, V J Cirillo, E A Ham.
Abstract
A dose-response relation was established between prostaglandins and formation of adenosine 3',5'-monophosphate in the mouse ovary. The prostaglandin antagonist, 7-oxa-13-prostynoic acid, blocked the stimulatory effect of prostaglandin E(1), prostaglandin E(2), and luteinizing hormone on adenosine 3',5'-monophosphate formation in a competitive manner. Kinetic studies made it possible to suggest that there is a single luteinizing-hormone-related prostaglandin receptor in mouse ovaries, and that activation of this prostaglandin receptor is an essential requirement in the action of luteinizing hormone to stimulate adenosine 3',5'-monophosphate formation and steroidogenesis.Entities:
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Year: 1970 PMID: 4317401 DOI: 10.1126/science.169.3948.883
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728