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Literature DB >> 4317383

Effects of glucagon, dibutyryl cyclic 3',5'-adenosine monophosphate, and theophylline on calcitonin secretion in vitro.

Abstract

The secretion of calcitonin by slices of porcine thyroid glands has been investigated. Calcitonin in the incubation medium was determined by radioimmunoassay. Secretion of calcitonin was diminished when calcium or magnesium was omitted and was increased stepwise as the concentration of calcium or magnesium in the incubation medium was increased. Calcitonin secretion was augmented substantially when either the quantity of thyroid tissue or volume of incubation medium was increased. Secretion of calcitonin was stimulated by glucagon, theophylline, and dibutyryl cyclic 3',5'-adenosine monophosphate. It is concluded that calcitonin secretion is regulated by the concentration of calcium and magnesium, that secretion may be inhibited by calcitonin or a precursor and that secretion can be stimulated by increasing the concentration of cyclic 3',5'-adenosine monophosphate in the parafollicular cells of the thyroid gland.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1970 PMID： 4317383 PMCID： PMC322609 DOI： 10.1172/JCI106353

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

30 in total

1. Purification of 131-I parathyroid hormone with microfine granules of precipitated silica.

Authors: R S Yalow; S A Berson
Journal: Nature Date: 1966-10-22 Impact factor: 49.962

2. Thyrocalcitonin activity in hypercalcemia produced by calcium salts, parathyroid hormone and vitamin D.

Authors: R Mittleman; A Chausmer; J Bellavia; S Wallach
Journal: Endocrinology Date: 1967-09 Impact factor: 4.736

3. Immunofluorescent localization of calcitonin in the 'C' cells of pig and dog thyroid.

Authors: G Bussolati; A G Pearse
Journal: J Endocrinol Date: 1967-02 Impact factor: 4.286

4. A new method for the measurement in vitro of pancreatic insulin secretion.

Authors: W Malaisse; F Malaisse-Lagae; P H Wright
Journal: Endocrinology Date: 1967-01 Impact factor: 4.736

5. Experimental hyperparathyroidism from multiple isologous parathyroid transplants: homeostatic effect of simultaneous thyroid transplants.

Authors: R F Gittes; I C Radde
Journal: Endocrinology Date: 1966-05 Impact factor: 4.736

6. Thyrocalcitonin: inhibitor of bone resorption in tissue culture.

Authors: J Friedman; L G Raisz
Journal: Science Date: 1965-12-10 Impact factor: 47.728

7. Thyrocalcitonin inhibition of bone resorption induced by parathyroid hormone in tissue culture.

Authors: M A Aliapoulios; P Goldhaber; P L Munson
Journal: Science Date: 1966-01-21 Impact factor: 47.728

8. The isolation and properties of thyrocalcitonin.

Authors: I Putter; E A Kaczka; R E Harman; E L Rickes; A J Kempf; L Chaiet; J W Rothrock; A W Wase; F J Wolf
Journal: J Am Chem Soc Date: 1967-09-27 Impact factor: 15.419

9. Thyrocalcitonin and the response to parathyroid hormone.

Authors: C Anast; C D Arnaud; H Rasmussen; A Tenenhouse
Journal: J Clin Invest Date: 1967-01 Impact factor: 14.808

10. A possible role for the adenylcyclase system in insulin secretion.

Authors: W J Malaisse; F Malaisse-Lagae; D Mayhew
Journal: J Clin Invest Date: 1967-11 Impact factor: 14.808

11 in total

1. Effect of glucagon on gastric and pancreatic secretion and peptic ulcer formation in cats.

Authors: S J Konturek; T Demitrescu; T Radecki; P Thor; A Pucher
Journal: Am J Dig Dis Date: 1974-06

Review 2. [Problems in calcitonin research].

Authors: H G Haas; M A Dambacher; J Guncaga; T Lauffenburger; C Lentner
Journal: Klin Wochenschr Date: 1972-01-01

10. Secretion of calcitonin and carcinoembryonic antigen in long-term organ culture of human medullary thyroid carcinoma: biochemical and immunocytochemical studies.

Authors: F Raue; G Boller; E Rix; H Schmidt-Gayk; R Ziegler
Journal: Klin Wochenschr Date: 1985-03-01

Effects of glucagon, dibutyryl cyclic 3',5'-adenosine monophosphate, and theophylline on calcitonin secretion in vitro.

1. Purification of 131-I parathyroid hormone with microfine granules of precipitated silica.

2. Thyrocalcitonin activity in hypercalcemia produced by calcium salts, parathyroid hormone and vitamin D.

3. Immunofluorescent localization of calcitonin in the 'C' cells of pig and dog thyroid.

4. A new method for the measurement in vitro of pancreatic insulin secretion.

5. Experimental hyperparathyroidism from multiple isologous parathyroid transplants: homeostatic effect of simultaneous thyroid transplants.

6. Thyrocalcitonin: inhibitor of bone resorption in tissue culture.

7. Thyrocalcitonin inhibition of bone resorption induced by parathyroid hormone in tissue culture.

8. The isolation and properties of thyrocalcitonin.

9. Thyrocalcitonin and the response to parathyroid hormone.

10. A possible role for the adenylcyclase system in insulin secretion.

1. Effect of glucagon on gastric and pancreatic secretion and peptic ulcer formation in cats.

Review 2. [Problems in calcitonin research].

Review 3. Glucagon: a "contaminant" comes of age.

4. Immunological phagocytosis: effect of drugs on phosphodiesterase activity.

5. Compound 48-80 decreases adenosine 3'5'-monophosphate formation in rat peritoneal mast cells.

6. Serum calcitonin concentrations in premature infants during the first 12 weeks of life.

7. Effect of propranolol and metoprolol on parathyroid hormone and calcitonin secretions in uraemic patients.

8. Serum calcitonin-lowering effect of magnesium in patients with medullary carcinoma of the thyroid.

9. Calcitonin and parathyroid hormone in newborn infants with fracture of the clavicle.

10. Secretion of calcitonin and carcinoembryonic antigen in long-term organ culture of human medullary thyroid carcinoma: biochemical and immunocytochemical studies.