Literature DB >> 431729

Thrombin-stimulated cell division involves proteolysis of its cell surface receptor.

K C Glenn, D D Cunningham.   

Abstract

A cell-surface component of molecular weight 43,000 is cleaved by thrombin on cells that divide after thrombin treatment, but is not cleaved on cells that are unresponsive to its mitogenic action. Studies with a photoreactive derivative of thrombin showed that its cell surface receptor has a molecular weight of 43,000. This indicates that thrombin must cleave its receptor to stimulate cell division.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 431729     DOI： 10.1038/278711a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  7 in total

1.  A low molecular weight proteinase inhibitor produced by T lymphocytes.

Authors:  D Ganea; M Teodorescu; S Dray
Journal:  Immunology       Date:  1986-01       Impact factor: 7.397

2.  Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells.

Authors:  J A Cooper; B M Sefton; T Hunter
Journal:  Mol Cell Biol       Date:  1984-01       Impact factor: 4.272

3.  alpha-Thrombin inhibits DNA synthesis in rat hepatocytes but not in hepatoma cells by receptor activation and proteolysis.

Authors:  Siddhartha Kar; Meifang Wang; Brian I Carr
Journal:  Mol Cell Biochem       Date:  2007-05-22       Impact factor: 3.396

4.  [T-lymphocyte activation. Studies on the function of mediator proteins (author's transl)].

Authors:  E Köttgen; H A Fabricius; R Stahn; W Gerok
Journal:  Klin Wochenschr       Date:  1981-06-15

5.  Effect of cell density on thrombin binding to a specific site on bovine vascular endothelial cells.

Authors:  J Isaacs; N Savion; D Gospodarowicz; M A Shuman
Journal:  J Cell Biol       Date:  1981-09       Impact factor: 10.539

6.  Modulation of morphological differentiation of human neuroepithelial cells by serine proteases: independence from blood coagulation.

Authors:  R J Grand; P W Grabham; M J Gallimore; P H Gallimore
Journal:  EMBO J       Date:  1989-08       Impact factor: 11.598

7.  Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.

Authors:  M M Simon; H Hoschützky; U Fruth; H G Simon; M D Kramer
Journal:  EMBO J       Date:  1986-12-01       Impact factor: 11.598
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.