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Literature DB >> 4316974

Induction of carcinomas in the nasal cavity of rats by dioxane.

Abstract

Six out of 120 rats fed dioxane in drinking water at levels of 0.75, 1.0, 1.4 or 1.8% developed carcinomas in the nasal cavity. Spontaneous tumors at this tissue localization have not been reported to occur in laboratory animals. The carcinomas were pre-eminently of epidermoid type with few adenocarcinomatous areas and epithelial papillomas. Four rats with carcinoma of the nasal cavity had hepatocellular carcinoma in addition.

Entities: Chemical Disease Species

Mesh：

Substances：
Dioxins

Year: 1970 PMID： 4316974 PMCID： PMC2008516 DOI： 10.1038/bjc.1970.19

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

11 in total

1. [SELECTIVE INDUCTION OF CARCINOMA OF THE PARANASAL SINUSES IN RATS WITH N,N'-DI-NITROSOPIPERAZINE, NITROSOPIPERIDINE, NITROSOMORPHOLINE, METHYLALLYL-, DIMETHYL- AND METHYLVINYL NITROSAMINE].

Authors: H DRUCKREY; S IVANKOVIC; H D MENNEL; R PREUSSMANN
Journal: Z Krebsforsch Date: 1964-05-08

2. A VISCOMETRIC STUDY OF HYDROGEN-BONDING PROPERTIES OF CARCINOGENIC NITROSAMINES AND RELATED COMPOUNDS.

Authors: M F ARGUS; J C ARCOS; A ALAM; J H MATHISON
Journal: J Med Chem Date: 1964-07 Impact factor: 7.446

3. The spectrum of hepatotoxicity.

Authors: H J Zimmerman
Journal: Perspect Biol Med Date: 1968 Impact factor: 1.416

4. Studies on the carcinogenic activity of protein-denaturing agents: hepatocarcinogenicity of dioxane.

Authors: M F Argus; J C Arcos; C Hochligeti
Journal: J Natl Cancer Inst Date: 1965-12 Impact factor: 13.506

5. Modification of chronic carbon tetrachloride hepatic injury by N,N'-diphenyl-p-phenylenediamine.

Authors: A D Hartman; N R Di Luzio; M L Trumbull
Journal: Exp Mol Pathol Date: 1968-12 Impact factor: 3.362

6. Mechanism of alkylation of nucleic acids by nitrosodimethylamine.

Authors: W Lijinsky; J Loo; A E Ross
Journal: Nature Date: 1968-06-22 Impact factor: 49.962

7. Increased susceptibility to carbon tetrachloride poisoning in the rat after pretreatment with oral phenobarbitone.

Authors: R C Garner; A E McLean
Journal: Biochem Pharmacol Date: 1969-03 Impact factor: 5.858

8. Theory of tumour initiation by chemical carcinogens: dependence of activity on structure of ultimate carcinogen.

Authors: A Dipple; P D Lawley; P Brookes
Journal: Eur J Cancer Date: 1968-10 Impact factor: 9.162

9. Studies on the denaturation of biological macromolecules by chemical carcinogens. 3. Optical rotatory dispersion and light-scattering changes of ovalbumin during denaturation and aggregation by water-soluble carcinogens.

Authors: J A Bemis; M F Argus; J C Arcos
Journal: Biochim Biophys Acta Date: 1966-10-10

Induction of carcinomas in the nasal cavity of rats by dioxane.

1. [SELECTIVE INDUCTION OF CARCINOMA OF THE PARANASAL SINUSES IN RATS WITH N,N'-DI-NITROSOPIPERAZINE, NITROSOPIPERIDINE, NITROSOMORPHOLINE, METHYLALLYL-, DIMETHYL- AND METHYLVINYL NITROSAMINE].

2. A VISCOMETRIC STUDY OF HYDROGEN-BONDING PROPERTIES OF CARCINOGENIC NITROSAMINES AND RELATED COMPOUNDS.

3. The spectrum of hepatotoxicity.

4. Studies on the carcinogenic activity of protein-denaturing agents: hepatocarcinogenicity of dioxane.

5. Modification of chronic carbon tetrachloride hepatic injury by N,N'-diphenyl-p-phenylenediamine.

6. Mechanism of alkylation of nucleic acids by nitrosodimethylamine.

7. Increased susceptibility to carbon tetrachloride poisoning in the rat after pretreatment with oral phenobarbitone.

8. Theory of tumour initiation by chemical carcinogens: dependence of activity on structure of ultimate carcinogen.

9. Studies on the denaturation of biological macromolecules by chemical carcinogens. 3. Optical rotatory dispersion and light-scattering changes of ovalbumin during denaturation and aggregation by water-soluble carcinogens.

10. Induction of tumors in the Syrian hamster with diethylnitrosamine (N-nitrosodiethylamine).

1. Carcinogenesis induced by trace contaminants in potable water.

2. Effects of dioxane on RNA synthesis in the rat liver.

3. Structural identification of p-dioxane-2-one as the major urinary metabolite of p-dioxane.

4. Examination of potential mechanisms of carcinogenicity of 1,4-dioxane in rat nasal epithelial cells and hepatocytes.

5. Carcinogenesis bioassay of chlorinated dibenzodioxins and related chemicals.

6. A carcinogenic potency database of the standardized results of animal bioassays.