Literature DB >> 4316681

Inactivating and mutagenic effects of nitrosoguanidine on simian virus 40.

P Tegtmeyer, C Dohan, C Reznikoff.   

Abstract

N-methyl-N'-nitro-N-nitrosoguanidine (NTG) in high concentrations inactivates extracellular simian virus 40. No mutants were found in stocks of virions partially inactivated by NTG under the experimental conditions employed. In contrast, NTG in low concentrations inhibits the intracellular replication of simian virus 40 and is an effective mutagen of the intracellular virus. Six temperature-sensitive mutants of simian virus 40 have been isolated for genetic studies of the virus and its interaction with mammalian cells.

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Year:  1970        PMID： 4316681      PMCID： PMC283113          DOI： 10.1073/pnas.66.3.745

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  Characterization of the simian virus 40-specific RNA in virus-yielding and transformed cells.

Authors:  Y Aloni; E Winocour; L Sachs
Journal:  J Mol Biol       Date:  1968-02-14       Impact factor: 5.469

2.  Structure of simian virus 40. II. Symmetry and components of the virus particle.

Authors:  F A Anderer; H D Schlumberger; M A Koch; H Frank; H J Eggers
Journal:  Virology       Date:  1967-07       Impact factor: 3.616

3.  The integrated state of viral DNA in SV40-transformed cells.

Authors:  J Sambrook; H Westphal; P R Srinivasan; R Dulbecco
Journal:  Proc Natl Acad Sci U S A       Date:  1968-08       Impact factor: 11.205

4.  The effect of interferon on SV-40 T antigen production in SV-40-transformed cells.

Authors:  M N Oxman; S Baron; P H Black; K K Takemoto; K Habel; W P Rowe
Journal:  Virology       Date:  1967-05       Impact factor: 3.616

5.  Studies on the transfer of subviral infectivity from SV40-induced hamster tumor cells to indicator cells.

Authors:  P Gerber
Journal:  Virology       Date:  1966-04       Impact factor: 3.616

6.  Thermal separation of the synthesis of papovavirus SV40 tumor and virus antigens.

Authors:  T Kitahara; J L Melnick
Journal:  Proc Soc Exp Biol Med       Date:  1965-12

7.  Diazomethane as the active agent in nitrosoguanidine mutagenesis and lethality.

Authors:  E Cerdá-Olmedo; P C Hanawalt
Journal:  Mol Gen Genet       Date:  1968-05-03

8.  Temperature-sensitive mutants of influenza A virus: isolation of mutants and preliminary observations on genetic recombination and complementation.

Authors:  R W Simpson; G K Hirst
Journal:  Virology       Date:  1968-05       Impact factor: 3.616

9.  Isolation and characterization of conditional-lethal mutants of Sindbis virus.

Authors:  B W Burge; E R Pfefferkorn
Journal:  Virology       Date:  1966-10       Impact factor: 3.616

10.  Replication and complementation of human adenoviruses and simian papovavirus at an elevated temperature.

Authors:  M Jerkofsky; F Rapp
Journal:  J Virol       Date:  1968-07       Impact factor: 5.103
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  35 in total

1.  Function of simian virus 40 gene A in transforming infection.

Authors:  P Tegtmeyer
Journal:  J Virol       Date:  1975-03       Impact factor: 5.103

2.  Temperature-sensitive mutants of simian virus 40 selected by transforming ability.

Authors:  N Yamaguchi; T Kuchino
Journal:  J Virol       Date:  1975-06       Impact factor: 5.103

3.  Analysis of simian virus 40 wild-type and mutant virions by agarose gel electrophoresis.

Authors:  M Zweig; S Barban; N P Salzman
Journal:  J Virol       Date:  1976-03       Impact factor: 5.103

4.  Regulation of tumor antigen synthesis by simain virus 40 gene A.

Authors:  P Tegtmeyer; M Schwartz; J K Collins; K Rundell
Journal:  J Virol       Date:  1975-07       Impact factor: 5.103

5.  Cellular proteins associated with simian virus 40 early gene products in newly infected cells.

Authors:  Y C Yang; P Hearing; K Rundell
Journal:  J Virol       Date:  1979-10       Impact factor: 5.103

6.  Modification of simian virus 40 protein A.

Authors:  P Tegtmeyer; K Rundell; J K Collins
Journal:  J Virol       Date:  1977-02       Impact factor: 5.103

7.  Autoregulation of simian virus 40 gene A by T antigen.

Authors:  S I Reed; G R Stark; J C Alwine
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205

8.  Programmed factor binding to simian virus 40 GC-box replication and transcription control sequences.

Authors:  R L Buchanan; J D Gralla
Journal:  J Virol       Date:  1990-01       Impact factor: 5.103

9.  Simian virus 40 deoxyribonucleic acid synthesis: the viral replicon.

Authors:  P Tegtmeyer
Journal:  J Virol       Date:  1972-10       Impact factor: 5.103

10.  Simian virus 40 deoxyribonucleic acid synthesis: analysis by gel electrophoresis.

Authors:  P Tegtmeyer; F Macasaet
Journal:  J Virol       Date:  1972-10       Impact factor: 5.103
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