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Literature DB >> 4315890

Chemical and biochemical changes in subcellular fractions of guinea pig liver during infection with Coxiella burneti.

Abstract

Livers of uninfected guinea pigs and of guinea pigs infected with Coxiella burneti were fractionated into smooth endoplasmic reticulum, rough endoplasmic reticulum (RER), pellet, and cell sap fractions. The ribonucleic acid (RNA) and protein of each fraction were determined, and the phosphorylase, glucose-6-phosphatase, and glucosyl transferase (glycogen synthetase) activities of each fraction were measured. Decreased RNA, protein, and enzyme activities were found in the RER and pellet fractions of infected livers, with the greatest differences in the RER. The evidence indicates a solubilization of the phosphorylase and synthetase, with the enzymes moving from the RER and glycogen-containing pellet fraction to the cell sap. The data suggest the RER as a target during Q fever.

Entities: Chemical Disease Species

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Year: 1970 PMID： 4315890 PMCID： PMC247555 DOI： 10.1128/jb.102.2.334-340.1970

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

27 in total

1. STUDIES ON UDPG: ALPHA-1,4-GLUCAN ALPHA-4-GLUCOSYLTRANSFERASE. VII. CONVERSION OF THE ENZYME FROM GLUCOSE-6-PHOSPHATE-DEPENDENT TO INDEPENDENT FORM IN LIVER.

Authors: S HIZUKURI; J LARNER
Journal: Biochemistry Date: 1964-11 Impact factor: 3.162

2. LOCUS OF BIOCHEMICAL CHANGE IN MICE DYING FROM STAPHYLOCOCCAL INFECTION.

Authors: S S LINDELL; I M SMITH; J W NELSON; M DELLE; J I ROUTH
Journal: Nature Date: 1964-01-11 Impact factor: 49.962

3. Glycogen studies on white rats infected with Plasmodium berghei.

Authors: T I MERCADO; T VON BRAND
Journal: Exp Parasitol Date: 1954-05 Impact factor: 2.011

Review 4. Recent developments in the measurement of nucleic acids in biological materials. A supplementary review.

Authors: H N Munro; A Fleck
Journal: Analyst Date: 1966-02 Impact factor: 4.616

5. Glucocorticoid control of the liver glycogen synthetase-activating system.

Authors: H J Mersmann; H L Segal
Journal: J Biol Chem Date: 1969-04-10 Impact factor: 5.157

6. An on-off mechanism for liver glycogen synthetase activity.

Authors: H J Mersmann; H L Segal
Journal: Proc Natl Acad Sci U S A Date: 1967-10 Impact factor: 11.205

7. Association of enzymes with rat liver glycogen isolated by rate-zonal centrifugation.

Authors: A A Barber; S A Orrell; E Bueding
Journal: J Biol Chem Date: 1967-09-25 Impact factor: 5.157

8. Depletion of glycogen synthetase and increase of glucose 6-phosphate dehydrogenase in livers of ethionine-treated mice.

Authors: H G Sie; A Hablanian
Journal: Biochem J Date: 1965-10 Impact factor: 3.857

9. Intracellular transport of secretory proteins in the pancreatic exocrine cell. I. Role of the peripheral elements of the Golgi complex.

Authors: J D Jamieson; G E Palade
Journal: J Cell Biol Date: 1967-08 Impact factor: 10.539

Chemical and biochemical changes in subcellular fractions of guinea pig liver during infection with Coxiella burneti.

1. STUDIES ON UDPG: ALPHA-1,4-GLUCAN ALPHA-4-GLUCOSYLTRANSFERASE. VII. CONVERSION OF THE ENZYME FROM GLUCOSE-6-PHOSPHATE-DEPENDENT TO INDEPENDENT FORM IN LIVER.

2. LOCUS OF BIOCHEMICAL CHANGE IN MICE DYING FROM STAPHYLOCOCCAL INFECTION.

3. Glycogen studies on white rats infected with Plasmodium berghei.

Review 4. Recent developments in the measurement of nucleic acids in biological materials. A supplementary review.

5. Glucocorticoid control of the liver glycogen synthetase-activating system.

6. An on-off mechanism for liver glycogen synthetase activity.

7. Association of enzymes with rat liver glycogen isolated by rate-zonal centrifugation.

8. Depletion of glycogen synthetase and increase of glucose 6-phosphate dehydrogenase in livers of ethionine-treated mice.

9. Intracellular transport of secretory proteins in the pancreatic exocrine cell. I. Role of the peripheral elements of the Golgi complex.

10. Glycogen synthesis from uridine diphosphate glucose. The distribution of the enzyme in liver cell fractions.

Review 1. Animal models of Q fever (Coxiella burnetii).

2. Changes in liver and L-cell plasma membranes during infection with Coxiella burnetii.

3. Ribonucleic acid and protein synthesis in guinea pig liver during Q fever.

Review 4. Q fever and Coxiella burnetii: a model for host-parasite interactions.

5. Changes in hepatic glycogen, protein, and ribonucleic acid synthesis, and some effects of cortisol, during Q fever.

6. Phosphorylation-dephosphorylation of nuclear proteins during infection (Q fever).