Hydrocephalus in mice inoculated neonatally by the oronasal route with reovirus type 1.

Mice inoculated neonatally by the oronasal route with reovirus type 1 or 2 developed typical acute disease. Fifteen percent of the mice recovered from the acute infection. No further disease was noted in mice infected with reovirus 2, but 9 percent of the survivors of reovirus I infections developed hydrocephalus at a mean time of 109 days after inoculation. Infectious virus could not be isolated from hydrocephalic mice.