Literature DB >> 4314985

Melatonin synthesis: adenosine 3',5'-monophosphate and norepinephrine stimulate N-acetyltransferase.

D C Klein, G R Berg, J Weller.   

Abstract

Treatment of cultured rat pineal glands with norepinephrine or dibutyryl adenosine 3',5'-monophosphate causes a six- to tenfold stimulation of N-acetyltransferase. This enzyme converts serotonin to N-acetylserotonin, the immediate precursor of melatonin. The increased synthesis of melatonin caused by norepinephrine treatment appears to be the result of stimulation of N-acetyltransferase by an adenosine 3',5'-monophosphate mechanism.

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Year:  1970        PMID： 4314985     DOI： 10.1126/science.168.3934.979

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  26 in total

Review 1.  Circadian rhythms of indoleamines and serotonin N-acetyltransferase activity in the pineal gland.

Authors:  T Deguchi
Journal:  Mol Cell Biochem       Date:  1979-09-28       Impact factor: 3.396

2.  Effect of different photoperiods on the diurnal rhythm of 5-methoxytryptamine in the pineal gland of golden hamsters (Mesocricetus auratus).

Authors:  F Raynaud; P Pévet
Journal:  J Neural Transm Gen Sect       Date:  1991

3.  Regulation of sensitivity to beta-adrenergic stimulation in induction of pineal N-acetyltransferase.

Authors:  J A Romero; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1975-05       Impact factor: 11.205

4.  Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling.

Authors:  Martin F Rath; Michael J Bailey; Jong-So Kim; Anthony K Ho; Pascaline Gaildrat; Steven L Coon; Morten Møller; David C Klein
Journal:  Endocrinology       Date:  2008-09-25       Impact factor: 4.736

5.  Fos-like immunoreactivity in cultured rat pinealocytes.

Authors:  A Tuulivaara; J Koistinaho
Journal:  Histochemistry       Date:  1991

6.  Pineal protein kinase: effect of enzymic phosphorylation on actinomycin D binding by, and template activity of, chromatin.

Authors:  J A Fontana; W Lovenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

7.  Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme A N-acetyltransferase activity.

Authors:  D C Klein; J L Weller; R Y Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

8.  A cyclic AMP-dependent protein kinase of the bovine pineal gland.

Authors:  J A Fontana; W Lovenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205

9.  Control of circadian change of serotonin N-acetyltransferase activity in the pineal organ by the beta--adrenergic receptor.

Authors:  T Deguchi; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

10.  Induction and superinduction of serotonin N-acetyltransferase by adrenergic drugs and denervation in rat pineal organ.

Authors:  T Deguchi; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205
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