Literature DB >> 4313191

Mechanism of action of 2-mercapto-1(beta-4-pyridethyl)benzimidazole: a reversible inhibitor of interferon activity.

R M Friedman, I Pastan.   

Abstract

2-mercapto-1(beta-4-pyridethyl)benzimidazole (MPB) inhibited the development of antiviral activity induced by interferon in chick cells. The MPB effect was reversed by washing the cells. The action of MPB was on a step immediately following interferon binding but before the cellular RNA and protein synthesis that appear to be required for interferon action. The step blocked by MPB possibly involves cellular phospholipid synthesis.

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Year:  1970        PMID： 4313191      PMCID： PMC286197          DOI： 10.1073/pnas.65.1.104

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  MECHANISM OF ACTION OF COLICINES.

Authors:  M NOMURA
Journal:  Proc Natl Acad Sci U S A       Date:  1964-12       Impact factor: 11.205

2.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
Journal:  J Biol Chem       Date:  1957-05       Impact factor: 5.157

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  The effects of substituted benzimidazoles on the growth of viruses and the nucleic acid metabolism of host cells.

Authors:  R A Bucknall
Journal:  J Gen Virol       Date:  1967-01       Impact factor: 3.891

5.  Interferon production and RNA inhibitors.

Authors:  S Walters; D C Burke; J J Skehel
Journal:  J Gen Virol       Date:  1967-07       Impact factor: 3.891

6.  Lipoamino acids as precursors in the synthesis of authentic proteins by homogenates of hen oviduct.

Authors:  R W Hendler
Journal:  Proc Natl Acad Sci U S A       Date:  1965-10       Impact factor: 11.205

7.  A reversible inhibitor of nucleic acid synthesis.

Authors:  R A Bucknall; S B Carter
Journal:  Nature       Date:  1967-03-18       Impact factor: 49.962

8.  Further purification of chick interferon.

Authors:  K H Fantes
Journal:  Nature       Date:  1965-09-18       Impact factor: 49.962

9.  Effects of actinomycin D and 2-mercapto-1-(beta-4-pyridethyl) benzimidazole on the incorporation of [3H]uridine by chick embryo cells.

Authors:  J J Skehel; A J Hay; D C Burke; L N Cartwright
Journal:  Biochim Biophys Acta       Date:  1967-07-18

10.  Interferon binding: the first step in establishment of antiviral activity.

Authors:  R M Friedman
Journal:  Science       Date:  1967-06-30       Impact factor: 47.728
  10 in total
  1 in total

Review 1.  Antiviral activity of interferons.

Authors:  R M Friedman
Journal:  Bacteriol Rev       Date:  1977-09
  1 in total

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