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Literature DB >> 4311794

Variation in properties of plaque progeny of PARA (defective simian papovavirus 40)-adenovirus 7.

Abstract

One hundred and twelve progeny from double plaque-purified clones were derived from the original PARA (defective simian papovavirus 40)-adenovirus 7 population. These progeny were found to differ in their oncogenic potential in newborn hamsters with progeny from 20 clones not inducing any tumors during 1 year of observation. The varying tumorigenicity of the individual clonal progeny was not related to the titer of PARA (particle aiding replication of adenovirus) in the inoculum. There was a perfect correlation between the tumor antigen content of the tumor cells and the antibody response of the tumor-bearing host. The tumors containing both adenovirus and simian papovavirus 40 (SV40) tumor antigens appeared earlier than those carrying only SV40 tumor antigen. Progeny from clones which induced mixed tumors also produced tumors which contained only SV40 tumor antigen. Three variants of PARA were isolated which induced the synthesis of SV40 tumor antigen in the cytoplasm of infected simian cells; all other clones yielded progeny which induced synthesis of SV40 tumor antigen in the nucleus.

Entities: Disease Species

Mesh：

Substances：
Antigens

Year: 1969 PMID： 4311794 PMCID： PMC375918

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

15 in total

1. INDUCTION BY ADENOVIRUS TYPE 7 OF TUMORS IN HAMSTERS HAVING THE ANTIGENIC CHARACTERISTICS OF SV40 VIRUS.

Authors: R J HUEBNER; R M CHANOCK; B A RUBIN; M J CASEY
Journal: Proc Natl Acad Sci U S A Date: 1964-12 Impact factor: 11.205

2. THE INCORPORATION OF SV40 MATERIAL INTO ADENOVIRUS 7 AS MEASURED BY INTRANUCLEAR SYNTHESIS OF SV40 TUMOR ANTIGEN.

Authors: F RAPP; J L MELNICK; J S BUTEL; T KITAHARA
Journal: Proc Natl Acad Sci U S A Date: 1964-12 Impact factor: 11.205

3. SV40-adenovirus "hybrids": presence of two genotypes and the requirement of their complementation for viral replication.

Authors: A Boeyé; J L Melnick; F Rapp
Journal: Virology Date: 1966-01 Impact factor: 3.616

8. Variants of defective simian papovavirus 40 (PARA) characterized by cytoplasmic localization of simian papovavirus 40 tumor antigen.

Authors: J S Butel; M J Guentzel; F Rapp
Journal: J Virol Date: 1969-11 Impact factor: 5.103

9. Studies of adenovirus SV40 hybrid viruses. II. Defectiveness of the hybrid particles.

Authors: W P Rowe; S G Bau
Journal: J Exp Med Date: 1965-11-01 Impact factor: 14.307

10. In vitro transformation by the adenovirus-SV40 hybrid viruses. II. Characteristics of the transformation of hamster cells by the adeno 2-, adeno 3-, and adeno 12-SV40 viruses.

Authors: P H Black; B J White
Journal: J Exp Med Date: 1967-04-01 Impact factor: 14.307

16 in total

9. Differential ability of a T-antigen transport-defective mutant of simian virus 40 to transform primary and established rodent cells.

Authors: R E Lanford; C Wong; J S Butel
Journal: Mol Cell Biol Date: 1985-05 Impact factor: 4.272

10. Demonstration of infectious deoxyribonucleic acid in transformed cells. I. Recovery of simian virus 40 from yielder and nonyielder transformed cells.

Authors: V A Boyd; J S Butel
Journal: J Virol Date: 1972-09 Impact factor: 5.103

Variation in properties of plaque progeny of PARA (defective simian papovavirus 40)-adenovirus 7.

1. INDUCTION BY ADENOVIRUS TYPE 7 OF TUMORS IN HAMSTERS HAVING THE ANTIGENIC CHARACTERISTICS OF SV40 VIRUS.

2. THE INCORPORATION OF SV40 MATERIAL INTO ADENOVIRUS 7 AS MEASURED BY INTRANUCLEAR SYNTHESIS OF SV40 TUMOR ANTIGEN.

3. SV40-adenovirus "hybrids": presence of two genotypes and the requirement of their complementation for viral replication.

4. Studies of adenovirus-SV40 hybrid viruses. 3. Transfer of SV40 gene between adenovirus types.

5. Antigenic analysis of tumors and sera from aimals inoculated with para-adenovirus populations.

6. Replication in simian cells of defective viruses in an SV40-adenovirus "hybrid" population.

7. Variation in the oncogenic potential of human adenoviruses carrying a defective SV40 genome (PARA).

8. Variants of defective simian papovavirus 40 (PARA) characterized by cytoplasmic localization of simian papovavirus 40 tumor antigen.

9. Studies of adenovirus SV40 hybrid viruses. II. Defectiveness of the hybrid particles.

10. In vitro transformation by the adenovirus-SV40 hybrid viruses. II. Characteristics of the transformation of hamster cells by the adeno 2-, adeno 3-, and adeno 12-SV40 viruses.

1. Role of simian virus 40 gene A function in maintenance of transformation.

2. Role of the simian virus 40 gene A product in regulation of DNA synthesis in transformed cells.

3. Biological and biophysical characterization of SV40 cytoplasmic T-antigen-inducing mutants of PARA-adenovirus 7.

Review 4. Biochemical aspects of viral transformation.

5. Quantitative transformation of primate cells by PARA (defective SV40)-adenovirus type 7.

6. Non-equivalence of nuclear import among nuclei in multinucleated skeletal muscle cells.

7. Density differences between hybrid and nonhybrid particles in two adenovirus-simian virus 40 hybrid populations.

8. Characterization of simian cells tranformed by temperature-sensitive mutants of simian virus 40.

9. Differential ability of a T-antigen transport-defective mutant of simian virus 40 to transform primary and established rodent cells.

10. Demonstration of infectious deoxyribonucleic acid in transformed cells. I. Recovery of simian virus 40 from yielder and nonyielder transformed cells.