Literature DB >> 4309480

Human diploid cell transformation by DNA extracted from the tumor virus SV40.

S Aaronson, S Todaro.   

Abstract

The DNA isolated from simian virus 40 (SV40) can transform human fibroblast cells in tissue culture. Clonal lines of DNA-transformed human cells have been obtained that have properties characteristic of cells transformed by whole virus. They all contain SV40 T-antigen, and infectious virus can be recovered by cocultivation. This is the first demonstration of a permanent genetic alteration produced in human cells by purified DNA.

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Year:  1969        PMID： 4309480     DOI： 10.1126/science.166.3903.390

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Infectivity of the DNA from four isolates of JC virus.

Authors:  R J Frisque; J D Martin; B L Padgett; D L Walker
Journal:  J Virol       Date:  1979-11       Impact factor: 5.103

2.  In vitro transformation of rat and mouse cells by DNA from simian virus 40.

Authors:  P J Abrahams; A J Van der Eb
Journal:  J Virol       Date:  1975-07       Impact factor: 5.103

Review 3.  Infectious diseases: annual review of significant publications.

Authors:  H A Reimann
Journal:  Postgrad Med J       Date:  1970-05       Impact factor: 2.401

Review 4.  Human cell transformation by simian virus 40--a review.

Authors:  G H Sack
Journal:  In Vitro       Date:  1981-01

5.  Susceptibility of human cell strains to transformation by simian virus 40 and simian virus 40 deoxyribonucleic acid.

Authors:  S A Aaronson
Journal:  J Virol       Date:  1970-10       Impact factor: 5.103

6.  Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

Authors:  R C Mulligan; P Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

7.  Identification of the simian virus 40 which replicates when simian virus 40-transformed human cells are fused with simian virus 40-transformed mouse cells or superinfected with simian virus 40 deoxyribonucleic acid.

Authors:  S Kit; T Kurimura; M Brown; D R Dubbs
Journal:  J Virol       Date:  1970-07       Impact factor: 5.103

8.  Fibrils attached to the nuclear pore prevent egress of SV40 particles from the infected nucleus.

Authors:  G G Maul
Journal:  J Cell Biol       Date:  1976-09       Impact factor: 10.539

Review 9.  Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update.

Authors:  Pere Llinàs-Arias; Manel Esteller
Journal:  Open Biol       Date:  2017-09       Impact factor: 6.411
  9 in total

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