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Literature DB >> 4309307

Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa.

Abstract

1. A procedure is described for the purification of an enzyme from Neurospora crassa that has three catalytic functions. These are 1-N-(5'-phosphoribosyl)-ATP pyrophosphohydrolase, 1-N-(5'-phosphoribosyl)-AMP cyclohydrolase and histidinol dehydrogenase (l-histidinol-NAD oxidoreductase, EC 1.1.1.23), and are responsible for the catalysis of reactions 2, 3 and 10 in the histidine pathway. The ratio of these three catalytic activities remains approximately the same throughout the purification procedure. Evidence is presented that the purified preparations contain a single protein exhibiting association-dissociation equilibria.

Entities: Chemical Species

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Year: 1969 PMID： 4309307 PMCID： PMC1184794 DOI： 10.1042/bj1140049

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

17 in total

7. Activities and some properties of adenylate cyclase and phosphodiesterase in muscle, liver and nervous tissues from vertebrates and invertebrates in relation to the control of the concentration of adenosine 3':5'-cyclic monophosphate.

Authors: J R Arch; E A Newsholme
Journal: Biochem J Date: 1976-09-15 Impact factor: 3.857

7 in total

Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa.

1. INTERMEDIATES IN THE EARLY STEPS OF HISTIDINE BIOSYNTHESIS.

2. A method for determining the sedimentation behavior of enzymes: application to protein mixtures.

3. Acetylornithinase of Escherichia coli: partial purification and some properties.

4. The biosynthesis of histidine: imidazoleacetol phosphate transaminase.

5. Organization of the histidine-3 region of Neurospora.

6. Studies on biosynthetic enzymes. I. Mutant forms of histidinol dehydrogenase from Neurospora crassa.

7. Gene-enzyme relationships in histidine biosynthesis in Aspergillus nidulans.

8. A cluster of genes controlling three enzymes in histidine biosynthesis in Saccharomyces cerevisiae.

9. The purification and properties of histidinol dehydrogenase from Neurospora crassa.

10. Amino acid substitutions in mutant forms of histidinol dehydrogenase from Neurospora crassa.

1. Organization and expression of a two-gene cluster in the arginine biosynthesis of Saccharomyces cerevisiae.

2. Purification and properties of histidinol dehydrogenases from psychrophilic, mesophilic and thermophilic bacilli.

3. The stereospecificity of nicotinamide-adenine dinucleotide-dependent oxidoreductases from plants.

Review 4. Chromosomal loci of Neurospora crassa.

5. Isolation of the Candida albicans histidinol dehydrogenase (HIS4) gene and characterization of a histidine auxotroph.

6. Analytical study of the degradation of nucleohistone during calf thymus chromatin autolysis.

7. Activities and some properties of adenylate cyclase and phosphodiesterase in muscle, liver and nervous tissues from vertebrates and invertebrates in relation to the control of the concentration of adenosine 3':5'-cyclic monophosphate.