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Literature DB >> 4308275

Vitamin D3-stimulated template activity of chromatin from rat intestine.

Abstract

Administration of vitamin D to rats deficient in this vitamin markedly increases the template activity for DNA-dependent RNA synthesis by rat intestinal mucosal chromatin. The maximum stimulation of template activity occurs three hours after a dose of 2000 international units of vitamin D(3) is given. These results support the concept that vitamin D functions by initiating the transcription of DNA into mRNA, which codes for functional protein(s) involved in calcium transport in the small intestine.

Entities: Chemical Species

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Year: 1969 PMID： 4308275 PMCID： PMC223595 DOI： 10.1073/pnas.63.2.528

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

1. Vitamin D and growth.

Authors: H STEENBOCK; D C HERTING
Journal: J Nutr Date: 1955-12-10 Impact factor: 4.798

2. The Biology of Isolated Chromatin: Chromosomes, biologically active in the test tube, provide a powerful tool for the study of gene action.

Authors: J Bonner; M E Dahmus; D Fambrough; R C Huang; K Marushige; D Y Tuan
Journal: Science Date: 1968-01-05 Impact factor: 47.728

2. Rapid enhancement of chick intestinal DNA-dependent RNA polymerase II activity by 1 alpha, 25-dihydroxyvitamin D3, in vivo.

Authors: J E Zerwekh; M R Haussler; T J Lindell
Journal: Proc Natl Acad Sci U S A Date: 1974-06 Impact factor: 11.205

3. The localization of 1,25-dihydroxycholecalciferol in bone cell nuclei of rachitic chicks.

Authors: J C Weber; V Pons; E Kodicek
Journal: Biochem J Date: 1971-11 Impact factor: 3.857

4. Transfer ribonucleic acid methylases of bone. Studies on vitamin A and D deficiency.

Authors: D S Bradford; B Hacker; I Clark
Journal: Biochem J Date: 1972-03 Impact factor: 3.857

5. Embryonic chick intestine in organ culture. A unique system for the study of the intestinal calcium absorptive mechanism.

Authors: R A Corradino
Journal: J Cell Biol Date: 1973-07 Impact factor: 10.539

5 in total

Vitamin D3-stimulated template activity of chromatin from rat intestine.

1. Vitamin D and growth.

2. The Biology of Isolated Chromatin: Chromosomes, biologically active in the test tube, provide a powerful tool for the study of gene action.

3. Biological activity of 25-hydroxycholecalciferol, a metabolite of vitamin D3.

4. 25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3.

5. Mechanism of action and metabolic fate of vitamin D.

6. The association of a metabolite of vitamin D3 with intestinal mucosa chromatin in vivo.

7. On the relationship between vitamin D action and actinomycin-sensitive processes.

8. Template properties of liver chromatin.

9. Biologically active metabolite of vitamin D3 from bone, liver, and blood serum.

10. Subcellular location of vitamin D and its metabolites in intestinal mucosa after a 10-IU dose.

1. The response of the small intestine to vitamin D. Isolation and properties of chick intestinal polyribosomes.

2. Rapid enhancement of chick intestinal DNA-dependent RNA polymerase II activity by 1 alpha, 25-dihydroxyvitamin D3, in vivo.

3. The localization of 1,25-dihydroxycholecalciferol in bone cell nuclei of rachitic chicks.

4. Transfer ribonucleic acid methylases of bone. Studies on vitamin A and D deficiency.

5. Embryonic chick intestine in organ culture. A unique system for the study of the intestinal calcium absorptive mechanism.