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Literature DB >> 4305674

Recombination between guanidine-resistant and dextran sulfate-resistant mutants of type 1 poliovirus.

D Sergiescu, A Aubert-Combiescu, R Crainic.

Abstract

Mixed infection of monkey kidney cells with two mutants of the LSc2ab strain of poliovirus, one resistant to guanidine and the other resistant to both dextran sulfate and 2-(alpha-hydroxybenzyl)-benzimidazole (HBB), yielded progeny in which the number of gua(r)dex(r) particles exceeded by a factor of 7 to 10 the expected number of similar particles occurring through spontaneous mutation; recombination would explain the fairly high excess of doubly mutant particles that was obtained. Scoring of HBB resistance in 50 gua(r)dex(r) clones suggested that, during recombination, resistance to dextran sulfate is not associated with HBB resistance.

Entities: Chemical Species

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Year: 1969 PMID： 4305674 PMCID： PMC375771

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

14 in total

1. CHARACTERS OF GUANIDINE RESISTANT MUTANTS OF TYPE 1 POLIOVIRUS.

Authors: F HORODNICEANU; D SERGIESCU; R KLEIN; M ZAMFIRESCU; A A COMBIESCU
Journal: Arch Gesamte Virusforsch Date: 1964

2. Genetic recombination with poliovirus type 1. Studies of crosses between a normal horse serum-resistant mutant and several guanidine-resistant mutants of the same strain.

Authors: N LEDINKO
Journal: Virology Date: 1963-05 Impact factor: 3.616

3. Genetic recombination with Newcastle disease virus, polioviruses, and influenza.

Authors: G K HIRST
Journal: Cold Spring Harb Symp Quant Biol Date: 1962

4. A genetic map of poliovirus temperature-sensitive mutants.

Authors: P D Cooper
Journal: Virology Date: 1968-08 Impact factor: 3.616

5. Mutation towards dextran sulphate resistance in type 1 poliovirus.

Authors: D Sergiescu; F Horodniceanu; R Crainic
Journal: Nature Date: 1967-07-15 Impact factor: 49.962

6. Genetic transfer of guanidine resistance from type 2 to type 1 poliovirus.

Authors: D Sergiescu; F Horodniceanu; R Klein; R Crainic
Journal: Arch Gesamte Virusforsch Date: 1966

7. [Probable existence of 2 RNA-replicases in poliovirus].

Authors: D Ménard; A Lwoff
Journal: C R Acad Hebd Seances Acad Sci D Date: 1967-05-08

8. Physiological characterization of heat-defective (temperature-sensitive) poliovirus mutants: preliminary classification.

Authors: P D Cooper; R T Johnson; D J Garwes
Journal: Virology Date: 1966-12 Impact factor: 3.616

Recombination between guanidine-resistant and dextran sulfate-resistant mutants of type 1 poliovirus.

1. CHARACTERS OF GUANIDINE RESISTANT MUTANTS OF TYPE 1 POLIOVIRUS.

2. Genetic recombination with poliovirus type 1. Studies of crosses between a normal horse serum-resistant mutant and several guanidine-resistant mutants of the same strain.

3. Genetic recombination with Newcastle disease virus, polioviruses, and influenza.

4. A genetic map of poliovirus temperature-sensitive mutants.

5. Mutation towards dextran sulphate resistance in type 1 poliovirus.

6. Genetic transfer of guanidine resistance from type 2 to type 1 poliovirus.

7. [Probable existence of 2 RNA-replicases in poliovirus].

8. Physiological characterization of heat-defective (temperature-sensitive) poliovirus mutants: preliminary classification.

9. Induction with nitrous acid of dextran sulfate resistance in type 1 poliovirus.

10. A drug gradient plaque test for the study of the behaviour of animal viruses towards synthetic inhibitors.

Review 1. Strength in numbers: Mechanisms of viral co-infection.

2. Natural genetic exchanges between vaccine and wild poliovirus strains in humans.

3. Generated Randomly and Selected Functionally? The Nature of Enterovirus Recombination.

4. Plaques Formed by Mutagenized Viral Populations Have Elevated Coinfection Frequencies.