Literature DB >> 4305077

Glucagon-sensitive adenyl cylase in plasma membrane of hepatic parenchymal cells.

S L Pohl, L Birnbaumer, M Rodbell.   

Abstract

The plasma membrane of hepatic parenchymal cells contains an adenyl cyclase system that is stimulated by glucagon. Adrenocorticotropin and epinephrine do not stimulate this adenyl cyclase, and very little cyclic phospho-diesterase activity is present in the membrane. These findings support the concept that glucagon exerts its regulatory action in the liver by stimulating adenyl cyclase activity in the plasma membrane.

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Year:  1969        PMID： 4305077     DOI： 10.1126/science.164.3879.566

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  22 in total

Review 1.  Minireview: Glucagon in stress and energy homeostasis.

Authors:  B J Jones; T Tan; S R Bloom
Journal:  Endocrinology       Date:  2012-01-31       Impact factor: 4.736

2.  Optimization of the native glucagon sequence for medicinal purposes.

Authors:  Joseph R Chabenne; Maria A DiMarchi; Vasily M Gelfanov; Richard D DiMarchi
Journal:  J Diabetes Sci Technol       Date:  2010-11-01

3.  The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding.

Authors:  Lutz Birnbaumer
Journal:  Biochim Biophys Acta       Date:  2006-10-04

4.  Adenylate cyclase activity in lymphocyte subcellular fractions. Characterization of non-nuclear adenylate cyclase.

Authors:  D E Snider; C W Parker
Journal:  Biochem J       Date:  1977-03-15       Impact factor: 3.857

5.  Ultracytochemistry of cyclic 3',5'-nucleotide phosphodiesterase activity in the planarian Dugesia lugubris (O. Schmidt).

Authors:  A Duma; J Moraczewski
Journal:  Histochemistry       Date:  1980

6.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

7.  Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa.

Authors:  C J Schwartz; D V Kimberg; H E Sheerin; M Field; S I Said
Journal:  J Clin Invest       Date:  1974-09       Impact factor: 14.808

8.  Localization of 3', 5'-cyclic nucleotide phosphodiesterase activity in isolated thyroid cells and intact thyroid tissue.

Authors:  A E Kalderon; S F Ravanshenas
Journal:  Histochemistry       Date:  1974-05-03

9.  [Regulation of tumor growth by adenosine-3',5'-monophosphate].

Authors:  P Chandra; D Gericke
Journal:  Naturwissenschaften       Date:  1972-05

10.  Glucagon-stimulable adenylyl cyclase in rat liver. Effects of chronic uremia and intermittent glucagon administration.

Authors:  R R Dighe; F J Rojas; L Birnbaumer; A J Garber
Journal:  J Clin Invest       Date:  1984-04       Impact factor: 14.808
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