Literature DB >> 4304445

Reversion in polyoma-transformed cells: retransformation, induced antigens and tumorigenicity.

G Marin, I MacPherson.   

Abstract

We studied the properties of two morphologically reverted cell clones isolated as chromosomal segregants from a "hybrid" clone of BHK 21/13 hamster fibroblasts, transformed with polyoma virus. Both clones were less tumorigenic than control transformed cells. They contained no detectable polyoma-specific complement-fixing antigen. Induced transplantation antigen also appeared to be lost or reduced. Both clones could be retransformed with polyoma virus, suggesting that their reversion is due to the loss of viral genes from the transformed cell.

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Year:  1969        PMID： 4304445      PMCID： PMC375744     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  8 in total

1.  CELL-TRANSFORMING ABILITY OF A TEMPERATURE-SENSITIVE MUTANT OF POLYOMA VIRUS.

Authors:  M FRIED
Journal:  Proc Natl Acad Sci U S A       Date:  1965-03       Impact factor: 11.205

2.  Application of a microtechnique to viral serological investigations.

Authors:  J L SEVER
Journal:  J Immunol       Date:  1962-03       Impact factor: 5.422

3.  Polyoma transformation of hamster cell clones--an investigation of genetic factors affecting cell competence.

Authors:  I MACPHERSON; M STOKER
Journal:  Virology       Date:  1962-02       Impact factor: 3.616

4.  Selection of morphologically normal cell lines from polyoma-transformed BHK21/13 hamster fibroblasts.

Authors:  G Marin; J W Littlefield
Journal:  J Virol       Date:  1968-01       Impact factor: 5.103

5.  Loss of T-antigen from somatic hybrids between mouse cells and SV40-transformed human cells.

Authors:  M C Weiss; B Ephrussi; L J Scaletta
Journal:  Proc Natl Acad Sci U S A       Date:  1968-04       Impact factor: 11.205

6.  Viral DNA in polyoma- and SV40-transformed cell lines.

Authors:  H Westphal; R Dulbecco
Journal:  Proc Natl Acad Sci U S A       Date:  1968-04       Impact factor: 11.205

7.  Transformation of polyploid hamster cells by polyoma virus.

Authors:  G Marin; C Basilico
Journal:  Nature       Date:  1967-10-07       Impact factor: 49.962

8.  Virus-specific RNA in cells productively infected or transformed by polyoma virus.

Authors:  T L Benjamin
Journal:  J Mol Biol       Date:  1966-04       Impact factor: 5.469
  8 in total
  5 in total

Review 1.  Somatic cell hybridization and problems of viral oncogenesis.

Authors:  G Marin
Journal:  In Vitro       Date:  1970

2.  New growth and viruses.

Authors:  M Stoker
Journal:  Br Med J       Date:  1970-09-05

3.  Loss of oncogenicity and concomitant increased immunogenicity of murine plasmacytoma cell lines.

Authors:  G D Sorenson; O S Pettengill; C C Cate
Journal:  Am J Pathol       Date:  1978-03       Impact factor: 4.307

Review 4.  Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology.

Authors:  Xixi Dou; Pingzhen Tong; Hai Huang; Lucas Zellmer; Yan He; Qingwen Jia; Daizhou Zhang; Jiang Peng; Chenguang Wang; Ningzhi Xu; Dezhong Joshua Liao
Journal:  J Cancer       Date:  2020-03-04       Impact factor: 4.207

Review 5.  Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.

Authors:  Shengming Zhu; Jiangang Wang; Lucas Zellmer; Ningzhi Xu; Mei Liu; Yun Hu; Hong Ma; Fei Deng; Wenxiu Yang; Dezhong Joshua Liao
Journal:  J Cancer       Date:  2022-07-04       Impact factor: 4.478
  5 in total

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