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Literature DB >> 4304160

Analogues of geranyl pyrophosphate as inhibitors of prenyltransferase.

G Popják, P W Holloway, R P Bond, M Roberts.

Abstract

Six analogues of geranyl pyrophosphate (the monophosphates of geraniol and tetrahydrogeraniol, and the pyrophosphates of nerol, octan-1-ol, tetrahydrogeraniol and citronellol) were synthesized, and were found to be inhibitors of pig liver prenyl- (geranyl-)transferase. The effects of each analogue were analysed in kinetic experiments, which showed the pyrophosphates of citronellol, tetrahydrogeraniol and octan-1-ol to be the most potent inhibitors. The results are interpreted to support a previous hypothesis that the main forces in the binding of substrates to prenyltransferase are non-specific lipophilic forces and a pyrophosphate-binding force.

Entities: Chemical Species

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Year: 1969 PMID： 4304160 PMCID： PMC1187516 DOI： 10.1042/bj1110333

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

7 in total

1. The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.

Authors: W W CLELAND
Journal: Biochim Biophys Acta Date: 1963-01-08

2. Computer programmes for processing enzyme kinetic data.

Authors: W W CLELAND
Journal: Nature Date: 1963-05-04 Impact factor: 49.962

3. Separation of the phosphoric esters on the filter paper chromatogram.

Authors: C S HANES; F A ISHERWOOD
Journal: Nature Date: 1949-12-31 Impact factor: 49.962

4. Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis.

Authors: J W Cornforth; R H Cornforth; C Donninger; G Popják
Journal: Proc R Soc Lond B Biol Sci Date: 1966-01-18

5. Synthesis of 10,11-dihydrofarnesyl pyrophosphate from 6,7-dihydrogeranyl pyrophosphate by prenyltransferase.

Authors: G Popják; P W Holloway; J M Baron
Journal: Biochem J Date: 1969-02 Impact factor: 3.857

6. An improved synthesis of isopentenyl pyrophosphate.

Authors: C Donninger; G Popják
Journal: Biochem J Date: 1967-11 Impact factor: 3.857

7. Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis.

Authors: G POPJAK; J W CORNFORTH; R H CORNFORTH; R RYHAGE; D S GOODMAN
Journal: J Biol Chem Date: 1962-01 Impact factor: 5.157

7 in total

5 in total

Analogues of geranyl pyrophosphate as inhibitors of prenyltransferase.

1. The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.

2. Computer programmes for processing enzyme kinetic data.

3. Separation of the phosphoric esters on the filter paper chromatogram.

4. Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis.

5. Synthesis of 10,11-dihydrofarnesyl pyrophosphate from 6,7-dihydrogeranyl pyrophosphate by prenyltransferase.

6. An improved synthesis of isopentenyl pyrophosphate.

7. Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis.

Review 1. "As I remember it" research on biosynthesis of fatty acids, triglycerides, squalene, and cholesterol.

2. Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway.

3. Biosynthesis of geraniol and nerol and beta-D-glucosides in Pelargonium graveolens and Rosa dilecta.

4. Synthesis of 10,11-dihydrofarnesyl pyrophosphate from 6,7-dihydrogeranyl pyrophosphate by prenyltransferase.

5. Artificial substrates for prenyltransferase.