Literature DB >> 4304157

A product-inhibition study of the mechanism of mitochondrial octanoly-coenzyme A synthetase.

A B Graham, M V Park.   

Abstract

By a study of the product-inhibition kinetics of the octanoyl-CoA synthetase from ox liver mitochondria, evidence was obtained consistent with the hypothesis that the enzyme reacts by a Bi Uni Uni Bi Ping Pong type of mechanism in which the order of addition and evolution of substrates and products is CoA, octanoate, octanoyl-CoA, ATP, PP(i) and AMP. There is also evidence that more than one molecule of CoA can add to the enzyme and that it may act as an allosteric activator.

Entities:  

Mesh：

Substances：

Year:  1969        PMID： 4304157      PMCID： PMC1187506          DOI： 10.1042/bj1110257

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  STUDIES OF THE ACETYL COENZYME A SYNTHETASE REACTION. I. ISOLATION AND CHARACTERIZATION OF ENZYME-BOUND ACETYL ADENYLATE.

Authors:  L T WEBSTER
Journal:  J Biol Chem       Date:  1963-12       Impact factor: 5.157

2.  The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.

Authors:  W W CLELAND
Journal:  Biochim Biophys Acta       Date:  1963-01-08

3.  The biosynthesis of acetyl and butyryl adenylates.

Authors:  L T WEBSTER; F CAMPAGNARI
Journal:  J Biol Chem       Date:  1962-04       Impact factor: 5.157

4.  Statistical estimations in enzyme kinetics.

Authors:  G N WILKINSON
Journal:  Biochem J       Date:  1961-08       Impact factor: 3.857

5.  A modification of the nitroprusside method of analysis for glutathione.

Authors:  R R GRUNERT; P H PHILLIPS
Journal:  Arch Biochem       Date:  1951-02

6.  Studies on palmitoyl-coenzyme A synthetase.

Authors:  J Bar-Tana; B Shapiro
Journal:  Biochem J       Date:  1964-12       Impact factor: 3.857

7.  The formation and reactions of a nonphosphorylated high energy form of succinyl coenzyme A synthetase.

Authors:  R W Moyer; R F Ramaley; L G Butler; P D Boyer
Journal:  J Biol Chem       Date:  1967-10-10       Impact factor: 5.157

8.  Studies on medium-chain fatty acyl-coenzyme a synthetase. Enzyme fraction II: mechanism of reaction and specific properties.

Authors:  J Bar-Tana; G Rose
Journal:  Biochem J       Date:  1968-09       Impact factor: 3.857

9.  Studies on medium-chain fatty acyl-coenzyme a synthetase. Enzyme fraction I: mechanism of reaction and allosteric properties.

Authors:  J Bar-Tana; G Rose
Journal:  Biochem J       Date:  1968-09       Impact factor: 3.857

10.  Synthesis and properties of palmityl adenylate, palmityl coenzyme A, and palmityl glutathione.

Authors:  P V VIGNAIS; I ZABIN
Journal:  Biochim Biophys Acta       Date:  1958-08
View more
  1 in total

1.  Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase.

Authors:  D A Vessey; M Kelley
Journal:  Biochem J       Date:  2001-07-01       Impact factor: 3.857
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.