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Literature DB >> 4303919

The effect of local blockage of motor nerve terminals.

Abstract

1. Electrophoretic application of tetrodotoxin (TTX) was used to study the effect of localized blockage of impulses in motor nerve terminals.2. Under suitable conditions it can be shown that local production of end-plate potentials ceases distal to the site of TTX application, while it continues without diminution at proximal sites of the same terminal arborization.3. It is concluded that electrotonic spread of an action potential wave along a motor nerve terminal is insufficient to elicit transmitter release. Active propagation in the terminals is an essential requirement for neuromuscular transmission.

Entities: Chemical Disease

Mesh：

Substances：
Tetrodotoxin

Year: 1968 PMID： 4303919 PMCID： PMC1365367 DOI： 10.1113/jphysiol.1968.sp008675

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

13 in total

10. Elucidation of the mechanism and site of action of quinuclidinyl benzilate (QNB) on the electrical excitability and chemosensitivity of the frog sartorius muscle.

Authors: G G Schofield; J E Warnick; E X Albuquerque
Journal: Cell Mol Neurobiol Date: 1981-06 Impact factor: 5.046

The effect of local blockage of motor nerve terminals.

1. A STUDY OF SPONTANEOUS MINIATURE POTENTIALS IN SPINAL MOTONEURONES.

2. LINEAR ELECTRICAL PROPERTIES OF STRIATED MUSCLE FIBRES OBSERVED WITH INTRACELLULAR ELECTRODES.

3. PROPAGATION OF ELECTRIC ACTIVITY IN MOTOR NERVE TERMINALS.

4. On the localization of acetylcholine receptors.

5. An electrophysiological investigation of mammalian motor nerve terminals.

6. An analysis of the end-plate potential recorded with an intracellular electrode.

7. The release of acetylcholine from nerve endings by graded electric pulses.

8. Tetrodotoxin and neuromuscular transmission.

9. Localized blockage of nerve impulses at the myoneural junction.

10. Potential changes recorded from the frog motor nerve terminal during its activation.

1. Single-pixel optical fluctuation analysis of calcium channel function in active zones of motor nerve terminals.

2. Activity-dependent modulation of the presynaptic potassium current in the frog neuromuscular junction.

3. Two different presynaptic calcium currents in mouse motor nerve terminals.

4. Ionic properties of the neuromuscular junction of the frog: effects of denervation and pH.

5. Profiles of evoked release along the length of frog motor nerve terminals.

6. Intradendritic recordings from hippocampal neurons.

7. Presynaptic currents in frog motor endings.

8. Electrical excitability of motor nerve terminals in the mouse.

9. Different quantal responses within single frog neuromuscular junctions.

10. Elucidation of the mechanism and site of action of quinuclidinyl benzilate (QNB) on the electrical excitability and chemosensitivity of the frog sartorius muscle.