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Literature DB >> 4303816

Poliovirus crystals within the endoplasmic reticulum of endothelial and mononuclear cells in the monkey spinal cord.

K Blinzinger, J Simon, D Magrath, L Boulger.

Abstract

The lumbar motor columns of a cynomolgus monkey that had become tetraplegic after experimental infection with a highly virulent strain of type 3 poliovirus were examined by electron microscopy. Crystalline aggregates of poliovirus occurred within the endoplasmic reticulum of endothelial cells as well as of mononuclear inflammatory cells. This finding suggests that the endoplasmic reticulum might be much more involved in poliovirus multiplication than has been previously supposed.

Entities: Disease Species

Mesh：

Year: 1969 PMID： 4303816 DOI： 10.1126/science.163.3873.1336

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

27 in total

1. Direct spread of reovirus from the intestinal lumen to the central nervous system through vagal autonomic nerve fibers.

Authors: L A Morrison; R L Sidman; B N Fields
Journal: Proc Natl Acad Sci U S A Date: 1991-05-01 Impact factor: 11.205

Review 2. Parallel mechanisms in neuropathogenesis of enteric virus infections.

Authors: L A Morrison; B N Fields
Journal: J Virol Date: 1991-06 Impact factor: 5.103

3. Light and electron microscopic studies of mouse CNS after subcutaneous administration of the E and M variants of the encephalomyocarditis virus.

Authors: M Adachi; B W Volk; C Y Tsai; D Amsterdam; K F Wellmann
Journal: Acta Neuropathol Date: 1973 Impact factor: 17.088

4. Discrepancies between the sites of replication and cytocidal action of encephalitogenic viruses.

Authors: K Blinzinger; J Simon; W Müller
Journal: Experientia Date: 1972-01-15

5. [New viewpoints on the problem of the origin and pathogenetic significance of inflammatory reaction in viral infections of the CNS. Immunofluorescence, morphological and virological studies on the model of experimental poliomyelitis].

Authors: J Simon; G Peters; K Blinzinger; L Boulger; D Magrath
Journal: Arch Psychiatr Nervenkr (1970) Date: 1970

Poliovirus crystals within the endoplasmic reticulum of endothelial and mononuclear cells in the monkey spinal cord.

1. Direct spread of reovirus from the intestinal lumen to the central nervous system through vagal autonomic nerve fibers.

Review 2. Parallel mechanisms in neuropathogenesis of enteric virus infections.

3. Light and electron microscopic studies of mouse CNS after subcutaneous administration of the E and M variants of the encephalomyocarditis virus.

4. Discrepancies between the sites of replication and cytocidal action of encephalitogenic viruses.

5. [New viewpoints on the problem of the origin and pathogenetic significance of inflammatory reaction in viral infections of the CNS. Immunofluorescence, morphological and virological studies on the model of experimental poliomyelitis].

6. Tubuloreticular structures in a case of bronchialadenom (carcinoid type).

7. Virus-like particles in brain tumours induced by N-ethyl-N-nitrosourea in rats.

8. Entry and release of poliovirus as observed by electron microscopy of cultured cells.

9. Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis.

10. Ultrastructural studies on the pathogenesis of poliomyelitis in monkeys infected with poliovirus.