| Literature DB >> 4303081 |
J D Flack, R Jessup, P W Ramwell.
Abstract
Prostaglandins and their C20:(omega)6 fatty acid precursors are present in rat adrenal glands. Small doses of prostaglandins (PGE(1), PGE(2), or PGF(1infinity) 1.4 to 2.4 micromolar) increased steroidogenesis in the superfused adrenal glands obtained from hypophysectomized rats. This effect was mimicked in part by both adrenocorticotropin and its postulated intracellular intermediate adenosine 3', 5'-cyclic monophosphate; all three responses were inhibited by cycloheximide.Entities:
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Year: 1969 PMID: 4303081 DOI: 10.1126/science.163.3868.691
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728