Literature DB >> 4300144

The effect of chlorpromazine on cerebral glucose, ATP, ADP, AMP and ATPase in the mouse.

A K Chowdhury, A Skinner, R G Spector, S L Yap.   

Abstract

1. Administration of chlorpromazine 10 mg/kg intraperitoneally to mice produced no alteration in cerebral adenosine triphosphate (ATP), adenosine diphosphate (ADP) or adenosine monophosphate (AMP). In these animals there was an increase in the glucose content of the supernatants of homogenates of liver and brain following acid hydrolysis.2. Chlorpromazine 40 mg/kg intraperitoneally did not affect Mg(++) activated adenosine triphosphatase (ATPase) activity in the brain.

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Year:  1968        PMID： 4300144      PMCID： PMC1703431          DOI： 10.1111/j.1476-5381.1968.tb07951.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

Review 1.  EFFECTS OF DRUGS ON METABOLISM OF THE BRAIN IN VITRO.

Authors:  J H QUASTEL
Journal:  Br Med Bull       Date:  1965-01       Impact factor: 4.291

2.  THE INFLUENCE OF CHLORPROMAZINE ON THE METABOLISM OF 5-HYDROXYTRYPTAMINE IN THE MOUSE.

Authors:  A L BARTLET
Journal:  Br J Pharmacol Chemother       Date:  1965-04

3.  Effects of chlorpromazine on metabolism in central nervous system.

Authors:  R G GRENELL; J MENDELSON; W D McELROY
Journal:  AMA Arch Neurol Psychiatry       Date:  1955-03

4.  The conversion of glucose carbon into protein in the brain and other organs of the rat.

Authors:  R VRBA; M K GAITONDE; D RICHTER
Journal:  J Neurochem       Date:  1962 Sep-Oct       Impact factor: 5.372

5.  An improved glucose-oxidase method for determining blood, C.S.F. and urine glucose levels.

Authors:  V MARKS
Journal:  Clin Chim Acta       Date:  1959-05       Impact factor: 3.786

6.  [The problem of energy transport within living cells].

Authors:  T BUCHER
Journal:  Adv Enzymol Relat Subj Biochem       Date:  1953

7.  Effect of some drugs on p-nitrophenylphosphatase activity in brain and live tissue of the rat with special reference to influence of phenothiazines on membranes of brain tissue.

Authors:  C de Waart; T M Brogt; J H Sietsma
Journal:  Acta Physiol Pharmacol Neerl       Date:  1967-12

8.  The effect of chlorpromazine on 14-C-glucose metabolism in mouse liver and brain.

Authors:  A Skinner; R G Spector
Journal:  Br J Pharmacol Chemother       Date:  1968-05

9.  Cerebral protein synthesis in anoxic-ischaemic brain injury in the rat.

Authors:  S L Yap; R G Spector
Journal:  J Pathol Bacteriol       Date:  1965-10

10.  Content of lactic acid and adenosine mono-, di- and tri-phosphates in anoxic-ischaemic rat brain.

Authors:  R G Spector
Journal:  J Pathol Bacteriol       Date:  1965-10
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  2 in total

1.  Influence of therapeutic and toxic doses of neuroleptics and antidepressants on energy metabolism of the isolated perfused rat brain.

Authors:  J Krieglstein; R Stock; H Rieger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

2.  The effects of phenobarbitone, leptazol, dexamphetamine, iproniazid, imipramine, LSD, chlorpromazine, reserpine and hydroxyzine on the in vivo levels of adenine nucleotides and phosphocreatine in the rat brain.

Authors:  W S Wilson
Journal:  Br J Pharmacol       Date:  1969-07       Impact factor: 8.739
  2 in total

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