| Literature DB >> 4298078 |
Abstract
Antibodies directed against human follicle-stimulating hormone (FSH) were demonstrated in rabbit serum by neutralization of biological activity. Antibodies that bound FSH-(131)I were produced in rabbits and guinea pigs by repeated injections of FSH. By (131)I immunochemical methods, we found that at least 90% of the FSH-(131)I-binding antibody failed to distinguish the four human glycoprotein hormones: FSH, luteinizing hormone, chorionic gonadotropin, and thyrotropin, purified as well as endogenous hormone in plasma. Neither growth hormone, adrenocorticotropin, nor a variety of glycoproteins or animal plasmas were able to react with these antibodies.Entities:
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Year: 1968 PMID: 4298078 PMCID: PMC297328 DOI: 10.1172/JCI105862
Source DB: PubMed Journal: J Clin Invest ISSN: 0021-9738 Impact factor: 14.808