Literature DB >> 4298078

Antibody to human follicle-stimulating hormone: cross-reactivity with three other hormones.

S Schlaff, S W Rosen, J Roth.   

Abstract

Antibodies directed against human follicle-stimulating hormone (FSH) were demonstrated in rabbit serum by neutralization of biological activity. Antibodies that bound FSH-(131)I were produced in rabbits and guinea pigs by repeated injections of FSH. By (131)I immunochemical methods, we found that at least 90% of the FSH-(131)I-binding antibody failed to distinguish the four human glycoprotein hormones: FSH, luteinizing hormone, chorionic gonadotropin, and thyrotropin, purified as well as endogenous hormone in plasma. Neither growth hormone, adrenocorticotropin, nor a variety of glycoproteins or animal plasmas were able to react with these antibodies.

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Year:  1968        PMID: 4298078      PMCID: PMC297328          DOI: 10.1172/JCI105862

Source DB:  PubMed          Journal:  J Clin Invest        ISSN: 0021-9738            Impact factor:   14.808


  13 in total

Review 1.  GLYCOPROTEINS: STRUCTURE, METABOLISM AND BIOLOGY.

Authors:  R G SPIRO
Journal:  N Engl J Med       Date:  1963-09-12       Impact factor: 91.245

2.  STUDIES OF AN INHIBITOR OF THE TWO ANTIBODY IMMUNOASSAY SYSTEM.

Authors:  C R MORGAN; R L SORENSON; A LAZAROW
Journal:  Diabetes       Date:  1964 Jan-Feb       Impact factor: 9.461

3.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

4.  Quantitative aspects of the reaction between insulin and insulin-binding antibody.

Authors:  S A BERSON; R S YALOW
Journal:  J Clin Invest       Date:  1959-11       Impact factor: 14.808

5.  Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors:  W M HUNTER; F C GREENWOOD
Journal:  Nature       Date:  1962-05-05       Impact factor: 49.962

6.  Starch gel electrophoresis in a discontinous system of buffers.

Authors:  M D POULIK
Journal:  Nature       Date:  1957-12-28       Impact factor: 49.962

7.  Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin.

Authors:  S L STEELMAN; F M POHLEY
Journal:  Endocrinology       Date:  1953-12       Impact factor: 4.736

8.  Radioimmunoassay for human follicle stimulating hormone.

Authors:  C Faiman; R J Ryan
Journal:  J Clin Endocrinol Metab       Date:  1967-03       Impact factor: 5.958

9.  Radioimmunoassay for human follicle-stimulating hormone.

Authors:  A R Midgley
Journal:  J Clin Endocrinol Metab       Date:  1967-02       Impact factor: 5.958

10.  Radioimmunoassay for luteinizing hormone in human plasma or serum: physiological studies.

Authors:  W D Odell; G T Ross; P L Rayford
Journal:  J Clin Invest       Date:  1967-02       Impact factor: 14.808

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