Literature DB >> 429588

Gas-liquid chromatographic measurement of lignocaine in small samples of canine myocardium after enzymatic digestion.

D W Holt, M Loizou, R K Wyse.   

Abstract

A method is described whereby lignocaine can be measured in small samples of canine myocardium. A proteolytic enzyme is used to digest the tissue, and the drug, together with an internal standard, is subsequently extracted into an organic solvent and measured by gas-liquid chromatography. The method is reproducible using tissue samples as small as 50 mg and appears to be suitable for the measurement of a number of drugs in small samples of tissue.

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Year:  1979        PMID： 429588      PMCID： PMC1145626          DOI： 10.1136/jcp.32.3.225

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  6 in total

1.  THE ESTIMATION OF LIDOCAINE AND PRILOCAINE IN BIOLOGICAL MATERIAL BY GAS CHROMATOGRAPHY.

Authors:  G SVINHUFVUD; B ORTENGREN; S E JACOBSSON
Journal:  Scand J Clin Lab Invest       Date:  1965       Impact factor: 1.713

2.  Distribution of lidocaine in blood and tissue after single doses and steady infusion.

Authors:  K Ahmad; F Medzihradsky
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1971-11

3.  Rapid micro-method for the measurement of phenobarbitone, primidone and phenytoin in blood plasma or serum by gas-liquid chromatography.

Authors:  D M Rutherford; R J Flanagan
Journal:  J Chromatogr       Date:  1978-09-21

4.  Determination of lidocaine in blood and tissues.

Authors:  N Benowitz; M Rowland
Journal:  Anesthesiology       Date:  1973-12       Impact factor: 7.892

5.  A simple method for gas chromatographic determination of lidocaine in tissues.

Authors:  E Naito; M Matsuki; K Shimoji
Journal:  Anesthesiology       Date:  1977-11       Impact factor: 7.892

6.  The extraction and analysis of benzodiazepines in tissues by enzymic digestion and high-performance liquid chromatography.

Authors:  M D Osselton; M D Hammond; P J Twitchett
Journal:  J Pharm Pharmacol       Date:  1977-08       Impact factor: 3.765
  6 in total
  1 in total

1.  High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in small tissue samples after enzymatic digestion.

Authors:  G C Storey; P C Adams; R W Campbell; D W Holt
Journal:  J Clin Pathol       Date:  1983-07       Impact factor: 3.411
  1 in total

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