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Literature DB >> 4293959

The biosynthesis of phosphatidic acid and phosphatidylinositol in mammalian pancreas.

Abstract

1. The labelling of guinea-pig pancreas phospholipids in vivo after intraperitoneal injection of [(32)P]orthophosphate is described. 2. Acyl-CoA synthetase activity in pancreas homogenates has been studied. There is no absolute requirement for added fatty acids, indicating an adequate supply of endogenous fatty acids in these preparations. 3. Phosphatidic acid is formed in guinea-pig pancreas preparations by two distinct routes, namely the acylation of l-3-glycerophosphate and the phosphorylation of 1,2-diglyceride. Phosphatidic acid formed by either mechanism is converted into phosphatidylinositol by guinea-pig pancreas in vitro. 4. The enzymes of pancreas that convert phosphatidic acid into phosphatidylinositol via CDP-diglyceride have been characterized. 5. Addition of bovine serum albumin is necessary in assaying certain of these enzymes.

Entities: Chemical Gene Species

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Year: 1967 PMID： 4293959 PMCID： PMC1198310 DOI： 10.1042/bj1050379

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

36 in total

9. Biosynthesis of lipids in plants. II. Incorporation of glycerophosphate-32-P into phosphatides by cell-free preparations from spinach leaves.

Authors: P S Sastry; M Kates
Journal: Can J Biochem Date: 1966-04

10. Pancreatic microsomes; an integrated morphological and biochemical study.

Authors: G E PALADE; P SIEKEVITZ
Journal: J Biophys Biochem Cytol Date: 1956-11-25

17 in total

1. Role of cytidine triphosphate and cytidine diphosphate in promoting inositol entry into microsomal phosphatidylinositol.

Authors: B J Holub
Journal: Lipids Date: 1975-08 Impact factor: 1.880

5. Comparisons of monoacylglycerols and diacylglycerols of varying fatty acid composition as substrates for the acylglycerol kinase(s) of rat brain.

Authors: H H Bishop; K P Strickland
Journal: Lipids Date: 1980-05 Impact factor: 1.880

The biosynthesis of phosphatidic acid and phosphatidylinositol in mammalian pancreas.

1. THE ENZYMATIC ACYLATION OF LYSOPHOSPHATIDYLINOSITOL.

2. SPECIFIC ASSAYS OF SOME PHOSPHATASES IN SUBCELLULAR FRACTIONS OF SMALL INTESTINAL MUCOSA.

3. The enzymatic synthesis of inositol phosphatide.

4. On the conversion of fructose to glucose by guinea pig intestine.

5. Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids.

6. The colorimetric determination of phosphorus.

7. Respiration and phosphorylation in preparations from Mammalian Brain.

8. Metabolism of phospholipids. 8. Biosynthesis of phosphatidylcholine in the intestinal mucosa.

9. Biosynthesis of lipids in plants. II. Incorporation of glycerophosphate-32-P into phosphatides by cell-free preparations from spinach leaves.

10. Pancreatic microsomes; an integrated morphological and biochemical study.

1. Role of cytidine triphosphate and cytidine diphosphate in promoting inositol entry into microsomal phosphatidylinositol.

2. Phosphatidylinositol synthesis by a mn-dependent exchange enzyme in castor bean endosperm.

3. Phosphatidylinositol synthesis in castor bean endosperm: cytidine diphosphate diglyceride:inositol transferase.

4. 1,2-diacylglycerol kinase of human erythrocyte membranes. Assay with endogenously generated substrate.

5. Comparisons of monoacylglycerols and diacylglycerols of varying fatty acid composition as substrates for the acylglycerol kinase(s) of rat brain.

6. The structure and biosynthesis of phosphatidyl inositol in cauliflower inflorescence.

7. Metabolism of glycerol-3-phosphate and phospholipids in a temperature-sensitive lysis mutant of Escherichia coli.

8. The mechanism of thyrotrophin action in relation to lipid metabolism in thyroid tissue.

9. Zymogen secretion and phospholipid metabolism in the pancreas. Phospholipids of the zymogen granule.

10. Phosphatidic acid and phosphatidylinositol metabolism in Schizosaccharomyces pombe.