Literature DB >> 429144

Radioimmunoassay for albumin-binding sites associated with HBsAg: correlation of results with the presence of e-antigen in serum.

A R Neurath, N Strick.   

Abstract

A radioimmunoassay for albumin-binding sites associated with hepatitis B surface antigen (HBsAg) is described. Polystyrene beads coated with glutaraldehyde-polymerized human serum albumin were incubated with diluted specimens of HBsAg-positive sera which contained either e-antigen (HBeAg) or anti-HBe or were negative for both HBeAg and anti-HBe as determined by rheophoresis. The quantity of HBsAg attached to the beads, determined by measuring the amount of 125I-labeled anti-HBs adsorbed during a subsequent incubation step, was related to the presence of HBeAg in the specimens.

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Year:  1979        PMID： 429144     DOI： 10.1159/000149024

Source DB:  PubMed          Journal:  Intervirology        ISSN： 0300-5526            Impact factor:   1.763


  11 in total

1.  Anti-albumin antibodies in chronic liver diseases: diagnostic significance of these antibodies in patients with conventional or immunosuppressive therapy.

Authors:  R Lenkei; L Buligescu; I Belascu; D Pospai; I Dobre
Journal:  Clin Exp Immunol       Date:  1981-02       Impact factor: 4.330

2.  Relationship of large hepatitis B surface antigen polypeptide to human serum albumin.

Authors:  J W Shih; P L Tan; J L Gerin
Journal:  Infect Immun       Date:  1980-05       Impact factor: 3.441

3.  Affinity chromatography of hepatitis B surface antigen from e-antigen-positive sera on insolubilized cross-linked albumin. Brief report.

Authors:  A R Neurath; N Strick
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

4.  Specificities of albumin receptors and albumin antibodies.

Authors:  S N Thung; M A Gerber
Journal:  Infect Immun       Date:  1981-06       Impact factor: 3.441

5.  Interaction of hepatitis B surface antigen with serum albumin of various species on polystylene latex particles.

Authors:  Y Ise; M Fukuda; T Suzuki
Journal:  Med Microbiol Immunol       Date:  1987       Impact factor: 3.402

6.  A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin.

Authors:  D H Persing; H E Varmus; D Ganem
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

7.  Hepatitis B virus vaccine: identification of HBsAg/a and HBsAg/d but not HBsAg/y subtype antigenic determinants on a synthetic immunogenic peptide.

Authors:  A M Prince; H Ikram; T P Hopp
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

8.  In vitro immune responses to hepatitis B surface antigen (Pre-S2 and S) following remote infection by hepatitis B virus in humans.

Authors:  T R Cupps; J H Hoofnagle; R W Ellis; W J Miller; L Seeff; A Guerrera; J L Gerin; S A Haas-Smith
Journal:  J Clin Immunol       Date:  1989-05       Impact factor: 8.317

9.  In vitro antigen-induced antibody responses to hepatitis B surface antigen in man. Kinetic and cellular requirements.

Authors:  T R Cupps; J L Gerin; R H Purcell; P K Goldsmith; A S Fauci
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808

10.  Interaction between various polymerized human albumins and hepatitis B surface antigen.

Authors:  M W Yu; J S Finlayson; J W Shih
Journal:  J Virol       Date:  1985-09       Impact factor: 5.103
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